Discovery and development of new drugs is a long, complex and expensive process. Information related to the three-dimensional structure of macromolecular drug targets and their ligands is now playing a central role from drug target identification up to lead optimisation. While X-ray crystallography remains a key tool to characterise macromolecules, small molecules, complexes and ligand binding, the use of complementary techniques such as circular dichroism and small angle X-ray scattering can lead to a more complete understanding of the process in question.
Structure-Based Drug Discovery
Protein Shape and Folding
Formulation and Processing
Medicinal products extracted from biological sources, called biopharmaceuticals or biologics, must be carefully produced to ensure that only high purity active material is generated. Biopharmaceutical manufacturing processes can have an impact on the amount of product-related variants in the final clinical material. Understanding and controlling amounts of these product-related variants is a major challenge in the development of biopharmaceutical products.Read more...
Elastin allows tissues in humans and other mammals to stretch and return to original shape e.g. during respiration or heart beats. The schematic on the right shows how many tropoelastin monomers (blue) can selfassemble and cross-link (red) to form elastin but the structure of the soluble precursor of elastin, tropoelastin, is not well understood.Read more...
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