Remote access for single-crystal diffraction is now a reality

First users open the door to super-efficient small molecule synchrotron research

Diamond’s industrial users can now control single-crystal diffraction experiments without even setting foot in the facility. Thanks to recent hardware and software developments on the Small-Molecule Single-Crystal Diffraction beamline (I19), users can run experiments from their own computers and collect single-crystal datasets in as little as 5 minutes.

The first users to take advantage of this new system were from Newcastle University; 278 miles away from Diamond and a 5 hour journey on a good day. According to the group’s coordinator, Dr Mike Probert: “We now know we can successfully control the experiments from our offices here, and with the recent upgrades we can collect the same number of datasets in one hour that last year would have taken us 24 hours.”

With remote access now a proven working model, small molecule single-crystal diffraction can now be opened up to academic and industrial users the world over.

  • Run experiments remotely with NoMachine
  • Faster sample changing with robot mounter and cryo-loader
  • Optional data conversion to standard Bruker image format
 
Figure 1: Natalie Johnson from Dr Probert's research group operating I19 from her desk at Newcastle University.
 
Single-crystal X-ray diffraction techniques are considered the definitive means of determining the structure of a molecular material. Applications extend across energy storage and carbon capture, pharmaceutical science, and superconductors. The researchers from Newcastle University’s School of Chemistry were working on a number of different samples, from inorganic materials to complex bioactive natural products.
 
Due to their size and at times structural complexity, small molecule crystals often produce a scattering signal too weak for conventional X-ray sources. This is where the power of the synchrotron comes in. Dr Probert and his team create crystal samples in their home labs and set aside those unsuitable for their own X-ray source. These are mounted on pins and shipped to Diamond in a dry dewar at approximately -190°C ready for loading when the beamtime session starts.
 
Dr Probert, who coordinates the block allocation to Diamond for a joint Newcastle and Durham user group, has worked on I19 over the last few years and sees this as a landmark moment for the beamline: “Increasing efficiency is the name of the game here, and sample preparation and shipping are two key players. But it’s the addition of the robot sample changer and cryogenic loading system that have really provided the step change on I19. The speed and ease of changing samples combined with the remote access mean we can really make the most of our beamtime.”
 
Dr Harriott Nowell, Senior Beamline Scientist for I19, has been working on getting the robot operational for remote access. She said: “With the robot now in place, users can collect diffraction data on up to 80 samples without anyone having to enter the hutch more than once. The robotic automation, together with the cryogenic sample handling, is set to provide an efficient way forward for remote access beamtime.”
 
I19’s Principal Beamline Scientist, Dr Dave Allan, sees the remote access route as a way to enable more scientists to use the facility: “With users now able to ship their samples and collect their data remotely, we can look at offering more beamtime sessions over a 24-hour period.”

The Industrial Liaison Team at Diamond

Would you like to know more about the I19 beamline, single molecule single-crystal diffraction or remote access? Do you perhaps have a problem that you are unable to solve? Then please get in touch with the Industrial Liaison Team at Diamond.
The Industrial Liaison team at Diamond is a group of professional, experienced scientists with a diverse range of expertise, dedicated to helping scientists and researchers from industry access the facilities at Diamond. We’re all specialists in different techniques and have a diverse range of backgrounds so we’re able to provide a multi-disciplinary approach to solving your research problems. We offer services ranging from full service; a bespoke experimental design, data collection, data analysis and reporting service through to providing facilities for you to conduct your own experiments.

We’re always happy to discuss any enquiries or talk about ways in which access to Diamond’s facilities may be beneficial to your business so please do give us a call on 01235 778797 or send us an e-mail. You can keep in touch with the latest development by following us on Twitter @DiamondILO orLinkedIn.