Alistair Siebert

profilephoto

Alistair is a Senior EM Scientist for the electron Bio-Imaging Centre (eBIC). He joined Diamond in June 2016 from the Division of Structural Biology at the University of Oxford.

Email: alistair.siebert@diamond.ac.uk
Tel: +44 (0) 1235 77 8356

Key Research Area

  • CryoEM
  1. Research
  2. Publications
Research -
Publications - +

Native structure of a retroviral envelope protein and its conformational change upon interaction with the target cell.
Riedel C, Vasishtan D, Siebert CA, Whittle C, Lehmann MJ, Mothes W, Grünewald K.
J Struct Biol. 2016 Jun 23. pii: S1047-8477(16)30123-X. doi: 10.1016/j.jsb.2016.06.017.

An introduction to sample preparation and imaging by cryo-electron microscopy for structural biology.
Thompson RF, Walker M, Siebert CA, Muench SP, Ranson NA.
Methods. 2016 May 1;100:3-15. doi: 10.1016/j.ymeth.2016.02.017.

Two distinct trimeric conformations of natively membrane-anchored full-length herpes simplex virus 1 glycoprotein B.
Zeev-Ben-Mordehai T, Vasishtan D, Hernández Durán A, Vollmer B, White P, Prasad Pandurangan A, Siebert CA, Topf M, Grünewald K.
Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):4176-81. doi: 10.1073/pnas.1523234113.

Acidic pH-Induced Conformations and LAMP1 Binding of the Lassa Virus Glycoprotein Spike.
Li S, Sun Z, Pryce R, Parsy ML, Fehling SK, Schlie K, Siebert CA, Garten W, Bowden TA, Strecker T, Huiskonen JT.
PLoS Pathog. 2016 Feb 5;12(2)

Structural Basis of Vesicle Formation at the Inner Nuclear Membrane.
Hagen C, Dent KC, Zeev-Ben-Mordehai T, Grange M, Bosse JB, Whittle C, Klupp BG, Siebert CA, Vasishtan D, Bäuerlein FJ, Cheleski J, Werner S, Guttmann P, Rehbein S, Henzler K, Demmerle J, Adler B, Koszinowski U, Schermelleh L, Schneider G, Enquist LW, Plitzko JM, Mettenleiter TC, Grünewald K.
Cell. 2015 Dec 17;163(7):1692-701. doi: 10.1016/j.cell.2015.11.029.

Independent Mechanisms Target SMCHD1 to Trimethylated Histone H3 Lysine 9-Modified Chromatin and the Inactive X Chromosome.
Brideau NJ, Coker H, Gendrel AV, Siebert CA, Bezstarosti K, Demmers J, Poot RA, Nesterova TB, Brockdorff N.
Mol Cell Biol. 2015 Dec;35(23):4053-68. doi: 10.1128/MCB.00432-15.

Structure of Ljungan virus provides insight into genome packaging of this picornavirus.
Zhu L, Wang X, Ren J, Porta C, Wenham H, Ekström JO, Panjwani A, Knowles NJ, Kotecha A, Siebert CA, Lindberg AM, Fry EE, Rao Z, Tuthill TJ, Stuart DI.
Nat Commun. 2015 Oct 8;6:8316. doi: 10.1038/ncomms9316.

Structure-based energetics of protein interfaces guides foot-and-mouth disease virus vaccine design.
Kotecha A, Seago J, Scott K, Burman A, Loureiro S, Ren J, Porta C, Ginn HM, Jackson T, Perez-Martin E, Siebert CA, Paul G, Huiskonen JT, Jones IM, Esnouf RM, Fry EE, Maree FF, Charleston B, Stuart DI.
Nat Struct Mol Biol. 2015 Oct;22(10):788-94. doi: 10.1038/nsmb.3096.

Extracellular vesicles: a platform for the structure determination of membrane proteins by Cryo-EM.
Zeev-Ben-Mordehai T, Vasishtan D, Siebert CA, Whittle C, Grünewald K.
Structure. 2014 Nov 4;22(11):1687-92. doi: 10.1016/j.str.2014.09.005.