Metals and breast cancer: With M. Farquharson, McMasters University, Canada, we are investigating the association of the levels of endogenous elements like Ca, Fe, Cu and Zn with a wide range of biomarkers in different breast cancer categories (eg invasive and in-situ, oestrogen receptor positive and negative). We are ultimately looking for associations that affect response to treatment, severity of disease and overall prognosis.
Metals and retinal function: With M. Ugarte, Moorfields Eye Hospital, we are looking into the role of metals in processes relating to retinal disease and aging. Recent experiments indicate a disruption of copper levels in one of the neurologically active layers of the retina associated with diabetic retinopathy.
Metal-based drugs for cancer therapy: With M. Hannon, PSIBS, Birmingham University, we are studying the action of certain metallocylinder drugs developed for cancer therapy. Synchrotron microprobe mapping is used to confirm drug delivery in the cell and XANES analysis is a way of investigating changes to the chemical environment of the metal atom.