A key mechanism by which a bacterial pathogen causes the deadly tropical disease melioidosis has been discovered by an international team of scientists.
“This is a fine example of where structural biology can play a crucial role in helping us to understand how diseases operate. The growth and achievements of this field depend heavily on access to facilities such as Diamond, where cutting edge tools are available and where we are pushing the boundaries of what is possible.”
Director of Life Sciences at Diamond, Professor David Stuart
These groups now plan to seek funding to continue the work and investigate potential applications of the toxin to fight other diseases, such as cancer, where it might usefully be employed in targeted therapies to prevent the proliferation of cancer cells.
'A Burkholderia pseudomallei Toxin Inhibits Helicase Activity of Translation Factor eIF4A'
David W. Rice et al.
Science 11 November 2011:
Vol. 334 no. 6057 pp. 821-824
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