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Inherited from: /Home/Beamlines/MX.html In this Section MX Home I02 - Macromolecular Crystallography I03 - Macromolecular Crystallography I04 - Macromolecular Crystallography I04-1 - Monochromatic MX I23 - Long Wavelength MX I24 - Microfocus MX B24 - Cryo-TXM Sample holders and magazines Available software Applications Support Facilities Working Group Case Studies Modulating GPCR activity Huntington's disease Proteins could offer novel antibiotic target More effective chemotherapy A puzzle solved in HIV research Of Beeswax and Synchrotrons The DNA-damage response Studying processes underlying cancer metastasis How can bird flu infect humans? EphA4 – the molecular transformer Getting a better understanding of molecular mechanisms Anticancer drug hope for a tumour suppressor gene mutant Towards better understanding of retroviral DNA integration and more effective antiviral drugs Repairing DNA AcrB: a multidrug efflux pump from pathogenic bacteria An intelligent weapon to combat tuberculosis Checking up on cell division Crystal structure determination of Superoxide Dismutase from C. elegans. Dealing with stress the bacterial way First de novo structure at Diamond Inhibitors of Aurora-A Protein Kinase for the Treatment of Cancer Keeping DNA under wraps SatNav for Cells Understanding the Mechanisms of Shigella Flexneri Structural basis for small GTPase guanine nucleotide exchange by DOCKfamily Structural insights into formation of an active signalling complex between Rac and phospholipase C-γ2 New structure helps explain so called children of the moon Serpins swap strands Structural basis for retroviral intasome assembly and integrase inhibitor action Structural Insights into the activation of phosphoinositide 3-kinase by influenza A viruses X-ray crystal structure and time-resolved spectroscopy of the blue carotenoid violerythrin Complex between Neisseria meningitidis factor H binding protein and two domains from human complement factor H Moving towards a green, hydrogen-based economy: structure of an oxygen-tolerant, highly active hydrogenase Propagation of repressive chromatin marks by PRC2 - how EED recognises histone tails Nbs1 – a new framework for understanding DNA-damage signalling and repair Crystallographic analysis of the interaction of splicing co-regulators polypyrimidine tract binding protein (PTB) and Raver1 Cell Semaphore Activation of a front line TB drug Architecture of a eukaryotic transpososome Structural insight into M-band assembly and mechanics from the titinobscurin- like-1 complex The structure of polyhedra microcrystals Improving our antibiotics How angiotensinogen fine-tunes our blood pressure for better and for worse Structural basis of Lassa fever nucleoprotein in transcription and immune suppression The mechanism of retroviral DNA integration through crystal structures of its key intermediates The structural basis for catalysis and substrate specificity of a rhomboid protease Towards a structural understanding of transport within the proton dependent oligopeptide transporter (POT) family The HIV Rev dimer structure and implications for multimeric binding to the Rev response element Structures of the TPR subunits of the anaphase promoting complex (APC/C) provide the basis for interpreting a 10 Å cryo-EM map of the APC/C Structure of AMPK and its regulation by ADP Toxin-antitoxin induced altruism in bacteria protects populations from bacteriophage infection TBL1 serves as a tetrameric scaffold for the assembly of the SMRT/NCoR transcriptional repression machinery The semaphorin-plexin system: a structural and functional analysis of cell guidance Studying molecular fossils- ancient lentiviral-CypA interactions Sugar sensing by our resident gut bacteria Virus family tree Structural study shows how plant pathogens evolve to attack our vegetables Fighting drug-resistant infections Contact Us Phase I - Latest Updates	Beamlines \| MX Case Study Inhibitors of Aurora-A Protein Kinase for the Treatment of Cancer Aurora-A is an essential enzyme which is required for human cells to multiply. Aurora-A has higher activity than normal in many human cancers and is a target for the development of anti-cancer drugs, some of which are in clinical trials. X-ray crystallography is used to characterise how these small molecules interact with Aurora-A, and these data provide information on how they work and allow the production of a new generation of more potent inhibitors. Electron density at 2.8 Å resolution around the site where one of the inhibitors binds. Knowledge of the geometry and neighbouring atoms will inform drug development. Magda Kosmopoulou and Richard Bayliss, Institute of Cancer Research, London Inherited from: /Home/Beamlines/MX/casestudies.html Bookmark with: del.icio.us Digg reddit StumbleUpon Ma.gnolia Email
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