Beamlines | I02 Publications

These publications are based on data gathered on beamline I02. If you are aware of any errors or publications that should be listed here, please send details to Sara Fletcher.


Total: 216 publications

Date Publication details
March 2012 Insights into dynein motor domain function from a 3.3-Å crystal structure Journal Paper, Helgo Schmidt,Emma S Gleave,Andrew P Carter, Nature Structural & Molecular Biology DOI: 10.1038/nsmb.2272
March 2012 Structure of the mitotic checkpoint complex Journal Paper, William C. H. Chao,Kiran Kulkarni,Ziguo Zhang,Eric H. Kong,David Barford, Nature DOI: 10.1038/nature10896
February 2012 An intrinsically labile alpha-helix abutting the BCL9-binding site of beta-catenin is required for its inhibition by carnosic acid Journal Paper, Marc de la Roche,Trevor J. Rutherford,Deepti Gupta,Dmitry B. Veprintsev,Barbara Saxty,Stefan M. Freund,Mariann Bienz, Nature Communications 3 DOI: 10.1038/ncomms1680
February 2012 Insights into Chi recognition from the structure of an AddAB-type helicase–nuclease complex Journal Paper, Kayarat Saikrishnan,Joseph T Yeeles,Neville S Gilhooly,Wojciech W Krajewski,Mark S Dillingham,Dale B Wigley, The EMBO Journal 31 DOI: 10.1038/emboj.2012.9
February 2012 Structural basis for the assembly and nucleic acid binding of the TREX-2 transcription-export complex Journal Paper, Andrew M Ellisdon,Lyudmila Dimitrova,Ed Hurt,Murray Stewart, Nature Structural & Molecular Biology 19 DOI: 10.1038/nsmb.2235
January 2012 The structure of the Bach2 POZ-domain dimer reveals an intersubunit disulfide bond Journal Paper, Gareth Rosbrook,Mark Stead,Stephen Carr,Stephanie Wright, Acta Crystallographica Section D Biological Crystallography 68 DOI: 10.1107/S0907444911048335
January 2012 The structure of the Bach2 POZ-domain dimer reveals an intersubunit disulfide bond Journal Paper, Gareth Rosbrook,Mark A. Stead,Stephen B. Carr,Stephanie C. Wright, Acta Crystallographica Section D Biological Crystallography 68 DOI: 10.1107/S0907444911048335
December 2011 Crystallographic Analysis of Polypyrimidine Tract-Binding Protein-Raver1 Interactions Involved in Regulation of Alternative Splicing Journal Paper, Amar Joshi,Miguel B. Coelho,Olga Kotik-Kogan,Peter Simpson,Stephen J. Matthews,Christopher W.J. Smith,Stephen Curry, Structure 19 DOI: 10.1016/j.str.2011.09.020
December 2011 Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis Journal Paper, Apirat Chaikuad,D. S. Froese,G. Berridge,Frank von Delft,Udo Oppermann,Wyatt Yue, Proceedings of the National Academy of Sciences DOI: 10.1073/pnas.1113921108
December 2011 The catalytic core of an archaeal 2-oxoacid dehydrogenase multienzyme complex is a 42-mer protein assembly Journal Paper, Nia L. Marrott,Jacqueline Marshall,Dmitri Svergun,Susan Crennell,David Hough,Michael Danson,Jean van den Elsen, FEBS Journal DOI: 10.1111/j.1742-4658.2011.08461.x
December 2011 Challenges of sulfur SAD phasing as a routine method in macromolecular crystallography Report, James Doutch,Mike Hough,Samar Hasnain,Richard W. Strange, Journal of Synchrotron Radiation 19 DOI: 10.1107/S0909049511049004
November 2011 Structure of the glycosyltransferase EryCIII in complex with its activating P450 homologue EryCII Journal Paper, Martin Moncrieffe,Maria-Jose Fernandez,Dieter Spiteller,Hiroyoshi Matsumura,Nicholas Gay,Ben Luisi,Peter Leadlay, Journal of Molecular Biology DOI: 10.1016/j.jmb.2011.10.036
November 2011 New Insights into the Structure of the Reaction Centre from Blastochloris viridis: Evolution in the Laboratory Journal Paper, Aleksander Roszak,Vladimira Moulisova,Adhie Reksodipuro,Alastair Gardiner,Ritsuko Fujii,Hideki Hashimoto,Neil Isaacs,Richard Cogdell, Biochemical Journal DOI: 10.1042/BJ20111540
November 2011 Structural Basis of Mannan-Binding Lectin Recognition by Its Associated Serine Protease MASP-1: Implications for Complement Activation Journal Paper, Alex Gingras,Umakhanth Venkatraman Girija,Anthony H. Keeble,Roshni Panchal,Daniel A. Mitchell,Peter Moody,Russell Wallis, Structure 19 DOI: 10.1016/j.str.2011.08.014
November 2011 Imidazo[1,5-a]quinoxalines as irreversible BTK inhibitors for the treatment of rheumatoid arthritis Journal Paper, Kyung-Hee Kim,Andreas Maderna,Mark E. Schnute,Martin Hegen,Shashi Mohan,Joy Miyashiro,Laura Lin,Evelyn Li,Sean Keegan,Jennifer Lussier,Christopher Wrocklage,Cheryl L. Nickerson-Nutter,Arthur J. Wittwer,Holly Soutter,Nicole Caspers,Seungil Han,Ravi Kurumbail,Kyri Dunussi-Joannopoulos,John Douhan,Allan Wissner, Bioorganic & Medicinal Chemistry Letters 21 DOI: 10.1016/j.bmcl.2011.09.008
November 2011 A novel technique combining high-resolution synchrotron x-ray microtomography and x-ray diffraction for characterization of micro particulates Journal Paper, David Merrifield,Vasuki Ramachandran,Kevin J Roberts,Wes Armour,Danny Axford,Mark Basham,Thomas Connolley,Gwyndaf Evans,Katherine McAuley,Robin Owen,James Sandy, Measurement Science and Technology 22 DOI: 10.1088/0957-0233/22/11/115703
November 2011 The Molecular Basis for the Endocytosis of Small R-SNAREs by the Clathrin Adaptor CALM Journal Paper, Sharon Miller,Daniela A. Sahlender,Stephen C. Graham,Stefan Honing,Margaret S. Robinson,Andrew A. Peden,David Owen, Cell 147 DOI: 10.1016/j.cell.2011.10.038
November 2011 Crystallization and preliminary X-ray analysis of the RXLR-type effector RXLR3 from the oomycete pathogen Journal Paper, Lennart Wirthmueller,Jonathan D. Jones,Mark Banfield, Acta Crystallographica Section F Structural Biology and Crystallization Communications 67 DOI: 10.1107/S1744309111035901
November 2011 Structure and Kinetic Stability of the p63 Tetramerization Domain Journal Paper, Eviata Najan,Andreas Christian Joerger, Journal of Molecular Biology DOI: 10.1016/j.jmb.2011.11.007
November 2011 Structure of the Phosphatase Domain of the Cell Fate Determinant SpoIIE from Bacillus subtilis Journal Paper, Vladimir Levdikov,Elena V. Blagova,Andrea E. Rawlings,Katie Jameson,James Tunaley,Darren J. Hart,Imrich Barak,Anthony Wilkinson, Journal of Molecular Biology DOI: 10.1016/j.jmb.2011.11.017
October 2011 An Enlarged, Adaptable Active Site in CYP164 Family P450 Enzymes, the Sole P450 in Mycobacterium leprae Journal Paper, Christopher Agnew,Andrew Warrilow,Nick Burton,David Lamb,Steven Kelly,Leo Brady, Antimicrobial Agents and Chemotherapy 56 (1) DOI: 10.1128/​AAC.05227-11
October 2011 Structural variability of the Ubiquitin Specific Protease DUSP-UBL double domains Journal Paper, Paul Elliott,Han Liu,Martyna W. Pastok,Guenter Grossmann,Daniel J. Rigden,Michael J. Clague,Sylvie Urbé,Igor L. Barsukov, FEBS Letters DOI: 10.1016/j.febslet.2011.09.040
October 2011 Structure determination of an intercalating ruthenium dipyridophenazine complex which kinks DNA by semiintercalation of a tetraazaphenanthrene ligand Journal Paper, James Hall,Kyra O'Sullivan,Abeer Naseer,Jayden Smith,J. M. Kelly,Christine J Cardin, Proceedings of the National Academy of Sciences DOI: 10.1073/pnas.1108685108
September 2011 Structure of a Streptomyces maltosyltransferase GlgE: a homologue of a genetically validated anti-tuberculosis target Journal Paper, K. Syson,C. E. M. Stevenson,M. Rejzek,S. A. Fairhurst,A. Nair,C. J. Bruton,R. A. Field,K. F. Chater,D. M. Lawson,S. Bornemann, Journal of Biological Chemistry DOI: 10.1074/jbc.M111.279315
September 2011 Non-equivalent role of inter- and intra-molecular hydrogen bonds in the insulin dimer interface Journal Paper, Antolikova, Zakova,Johan Turkenburg,C. J. Watson,I. Hanclova,M. Sanda,A. Cooper,T. Kraus, Brzozowski,J. Jiracek, Journal of Biological Chemistry DOI: 10.1074/jbc.M111.265249
September 2011 Altering the stability of the Cdc8 overlap region modulates the ability of this tropomyosin to bind co-operatively to actin and regulate myosin Journal Paper, Daniel A. East,Duncan Sousa,Stephen Martin,Thomas Edwards,William Lehman,Daniel P. Mulvihill, Biochemical Journal 438 DOI: 10.1042/BJ20101316
September 2011 Regulation of lipid binding underlies the activation mechanism of class IA PI3-kinases. Journal Paper, Wai-Ching Hon,Alex Berndt,Roger Williams, Oncogene
September 2011 Carbon monoxide poisoning is prevented by the energy costs of conformational changes in gas-binding haemproteins Journal Paper, Svetlana Antonyuk,Neil Rustage,C. A. Petersen,J. L. Arnst,Derren Heyes,R. Sharma,Neil Berry, Scrutton,Robert Eady,C. R. Andrew,Samar Hasnain, Proceedings of the National Academy of Sciences DOI: 10.1073/pnas.1109051108
September 2011 The three-dimensional structure of mannosyl-3-phosphoglycerate phosphatase from <i>Thermus thermophilus</i> HB27: a new member of the Haloalkanoic Acid Dehalogenase Superfamily Journal Paper, Susana Goncalves,Ana Esteves,Helena Santos,Nuno Borges,Pedro Matias, Biochemistry DOI: 10.1021/bi201171h
September 2011 Crystal structure of a bacterial homologue of the bile acid sodium symporter ASBT Journal Paper, Nien-Jen Hu,So Iwata,Alex Cameron, Drew, Nature DOI: 10.1038/nature10450
September 2011 Structural basis for cell surface patterning through NetrinG–NGL interactions Journal Paper, Elena Seiradake,Charlotte H Coles,Pavel V Perestenko,Karl Harlos,Robert Andrew Jeffrey McIlhinney,Alexandru Aricescu,Yvonne Jones, The EMBO Journal DOI: 10.1038/emboj.2011.346
September 2011 A widespread family of bacterial cell wall assembly proteins Journal Paper, Yoshikazu Kawai,Jon Marles-Wright,Robert M Cleverley,Robyn Emmins,Shu Ishikawa,Masayoshi Kuwano,Nadja Heinz,Nhat Khai Bui,Christopher N Hoyland,Naotake Ogasawara,Rick Lewis,Waldemar Vollmer,Richard A Daniel,Jeff Errington, The EMBO Journal DOI: 10.1038/emboj.2011.358
August 2011 The crystal structure of the TetR family transcriptional repressor SimR bound to DNA and the role of a flexible N-terminal extension in minor groove binding Journal Paper, Tung Le,M. A. Schumacher,David Lawson,R. G. Brennan,Mark Buttner, Nucleic Acids Research DOI: 10.1093/nar/gkr640
August 2011 Structures of Phytophthora RXLR effector proteins: a conserved but adaptable fold underpins functional diversity Journal Paper, Laurence Boutemy,S. R. F. King,J. Win,Richard Hughes,T. A. Clarke,T. M. A. Blumenschein,S. Kamoun,Mark Banfield, Journal of Biological Chemistry DOI: 10.1074/jbc.M111.262303
August 2011 Correlation of in situ mechanosensitive responses of the Moraxella catarrhalis adhesin UspA1 with fibronectin and receptor CEACAM1 binding Journal Paper, Christopher Agnew,Elena Borodina,Nathan Zaccai,Rebecca Conners,Nick Burton,J. A. Vicary,David Cole,Massimo Antognozzi,Mumtaz Virji,R. L. Brady, Proceedings of the National Academy of Sciences DOI: 10.1073/pnas.1106341108
August 2011 Activation of nitrofurazone by azoreductases: multiple activities in one enzyme Journal Paper, Ali Ryan,Elise Kaplan,Nicola Laurieri,Ed Lowe,Edith Sim, Scientific Reports 1 DOI: 10.1038/srep00063
July 2011 Structure of the PilM-PilN Inner Membrane Type IV Pilus Biogenesis Complex from Thermus thermophilus Journal Paper, Vijaykumar Karuppiah,Jeremy Derrick, Journal of Biological Chemistry 286 DOI: 10.1074/jbc.M111.243535
July 2011 Structural and Functional Analyses of the Second-generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572) Journal Paper, Stephen Hare,S. J. Smith,M. Metifiot,A. Jaxa-Chamiec,Y. Pommier,S. H. Hughes,Peter Cherepanov, Molecular Pharmacology DOI: 10.1124/mol.111.073189
July 2011 Features of the Streptomyces hygroscopicus HtpG reveal how partial geldanamycin resistance can arise with mutation to the ATP binding pocket of a eukaryotic Hsp90 Journal Paper, Stefan Millson,C.-S. Chua,Mark Roe,S. Polier,S. Solovieva,L. H. Pearl,T.-S. Sim,C. Prodromou,P. W. Piper, The FASEB Journal DOI: 10.1096/fj.11-188821 PMID: 21778327
July 2011 Multiple Factors Confer Specific Cdc42 and Rac Protein Activation by Dedicator of Cytokinesis (DOCK) Nucleotide Exchange Factors Journal Paper, Kiran Kulkarni,Jingjie Yang,Ziguo Zhang,David Barford, Journal of Biological Chemistry 286 DOI: 10.1074/jbc.M111.236455
July 2011 Crystallographic determination of the disease-associated T1184R variant of complement regulator factor H Journal Paper, Hugh Morgan,Jingzi Jiang,Andrew P. Herbert,David Kavanagh,Dušan Uhrin,Paul N. Barlow,Jonathan Hannan, Acta Crystallographica Section D Biological Crystallography 67 DOI: 10.1107/S0907444911015423 PMID: 21697597
July 2011 The Trypanocidal Drug Suramin and Other Trypan Blue Mimetics Are Inhibitors of Pyruvate Kinases and Bind to the Adenosine Site Journal Paper, Hugh Morgan,Iain McNae,Matthew Nowicki,W. Zhong,P. A. M. Michels,D. S. Auld,L. A. Fothergill-Gilmore,Malcolm Walkinshaw, Journal of Biological Chemistry 286 DOI: 10.1074/jbc.M110.212613 PMID: PMC3173065
July 2011 Crystal Structure of Serratia fonticola Sfh-I: Activation of the Nucleophile in Mono-Zinc Metallo-beta-Lactamases Journal Paper, Fatima Fonseca,Elizabeth Bromley,Maria José Saavedra,António Correia,Jim Spencer, Journal of Molecular Biology DOI: 10.1016/j.jmb.2011.06.043
June 2011 X-ray Crystallographic Structure of the Murine Norovirus protease at 1.66 Å Resolution and Functional Studies of the &#946;-ribbon Thesis, Gabriela Baeza, null
June 2011 Structure of a bacterial cell surface decaheme electron conduit Journal Paper, Thomas A. Clarke,Marcus J. Edwards,Andrew J. Gates,Andrea Hall,Gaye F. White,Justin Bradley,Catherine L. Reardon,Liang Shi,Alexander S. Beliaev,Matthew J. Marshall,Zheming Wang,Nicholas J. Watmough,James K. Fredrickson,John M. Zachara,Julea N. Butt,David J. Richardson, Proceedings of the National Academy of Sciences 108 DOI: 10.1073/pnas.1017200108
June 2011 Simultaneous X-ray diffraction from multiple single crystals of macromolecules Journal Paper, Karthik Paithankar,Henning O. Sørensen,Jonathan P. Wright,Søren Schmidt,Henning F. Poulsen,Elspeth F. Garman, Acta Crystallographica Section D Biological Crystallography 67 DOI: 10.1107/S0907444911015617
June 2011 The Virulence Factor PEB4 (Cj0596) and the Periplasmic Protein Cj1289 Are Two Structurally Related SurA-like Chaperones in the Human Pathogen Campylobacter jejuni Journal Paper, A. Kale,C. Phansopa,C. Suwannachart,C. J. Craven,J. B. Rafferty,D. J. Kelly, Journal of Biological Chemistry 286 DOI: 10.1074/jbc.M111.220442
June 2011 The N-Terminus of the RNA Polymerase from Infectious Pancreatic Necrosis Virus Is the Determinant of Genome Attachment Journal Paper, Stephen Graham,L. Sarin,Mohammad Bahar,Reg A. Myers,Dave Stuart,Dennis H. Bamford,Jonathan Grimes,Peter D. Nagy, PLoS Pathogens 7 DOI: 10.1371/journal.ppat.1002085
June 2011 Structure of a Pentavalent G-Actin*MRTF-A Complex Reveals How G-Actin Controls Nucleocytoplasmic Shuttling of a Transcriptional Coactivator Journal Paper, Stephane Mouilleron,Carola Langer,Sebastian Guettler,Neil McDonald,Richard Treisman, Science Signaling 4 DOI: 10.1126/scisignal.2001750 PMID: 21673315
June 2011 Mapping Lipid and Detergent Molecules at the Surface of Membrane Proteins Conference Paper, Richard Cogdell, null PMID: 21599648
May 2011 Assessment of radiation damage behaviour in a large collection of empirically optimized datasets highlights the importance of unmeasured complicating effects Journal Paper, Tobias Krojer,Frank von Delft, Journal of Synchrotron Radiation 18 (3) DOI: 10.1107/S0909049511008235
May 2011 Analysis of Streptomyces coelicolor Phosphopantetheinyl Transferase, AcpS, Reveals the Basis for Relaxed Substrate Specificity Journal Paper, Patrick Dall'Aglio,Christopher J. Arthur,Christopher Williams,Konstantinos Vasilakis,Hannah J. Maple,John Crosby,Matthew P. Crump,Andrea Hadfield, Biochemistry 50 DOI: 10.1021/bi2003668
May 2011 Multiple factors confer specific Cdc42 and Rac activation by Dock exchange factors Journal Paper, Kiran Kulkarni,Jing Yang,Ziguo Zhang,David Barford, Journal of Biological Chemistry DOI: 10.1074/jbc.M111.236455
April 2011 Cloning, purification, crystallization and preliminary crystallographic analysis of the human histone deacetylase sirtuin 1 Journal Paper, Kenneth Holbourn,Matthew Lloyd,Andrew Thompson,Michael Threadgill,Ravi Acharya, Acta Crystallographica Section F Structural Biology and Crystallization Communications 67 (4) DOI: 10.1107/S1744309111003277
April 2011 Proteoglycan-Specific Molecular Switch for RPTP  Clustering and Neuronal Extension Journal Paper, C. H. Coles,Y. Shen,A. P. Tenney,Christian Siebold,G. C. Sutton,W. Lu,J. T. Gallagher,E. Y. Jones,J. G. Flanagan,Alexandru Aricescu, Science 332 DOI: 10.1126/science.1200840
April 2011 Structural insights into the retroviral DNA integration apparatus Journal Paper, Peter Cherepanov,Goedele Maertens,Stephen Hare, Current Opinion in Structural Biology 21 DOI: 10.1016/j.sbi.2010.12.005
April 2011 From Crystal Packing to Molecular Recognition: Prediction and Discovery of a Binding Site on the Surface of Polo-Like Kinase 1 Journal Paper, Pawel Sledz,Christopher Stubbs,Steffen Lang,Yong-Qing Yang,Grahame McKenzie,Ashok Venkitaraman,Marko Hyvonen,Chris Abell, Angewandte Chemie 123 (17) DOI: 10.1002/ange.201008019
April 2011 Expression, crystallization and preliminary X-ray data analysis of NT-ALS9, a fungal adhesin from Candida albicans Journal Paper, Paula Salgado,Robert Yan,Rowantree Niall,Ernesto Cota-Segura, Acta Crystallographica Section F Structural Biology and Crystallization Communications DOI: 10.1107/S1744309111003460
March 2011 Asparagine and Aspartate Hydroxylation of the Cytoskeletal Ankyrin Family Is Catalyzed by Factor-inhibiting Hypoxia-inducible Factor. Journal Paper, Ming Yang,Wei Ge,Rasheduzzaman Chowdhury,Timothy Claridge,Holger Kramer,Bernhard Schmierer, McDonough,Lingzhi Gong,Benedikt Kessler,Peter Ratcliffe,Mathew Coleman,Christopher Schofield, Journal of Biological Chemistry 286 DOI: 10.1074/jbc.M110.193540
March 2011 Subunit-selective N-terminal domain associations organize the formation of AMPA receptor heteromers. Journal Paper, Maxim Rossmann,Madhav Sukumaran,A Penn, Veprintsev,Madan Babu,Ingo Greger, The EMBO Journal 30 DOI: 10.1038/emboj.2011.16
March 2011 Dynamics and allosteric potential of the AMPA receptor N-terminal domain Journal Paper, Madhav Sukumaran,Maxim Rossmann,I shrivastava,A Dutta,I Bahar,Ingo Greger, The EMBO Journal 30 DOI: 10.1038/emboj.2011.17
March 2011 Helix-mediated protein-protein interactions as targets for intervention using foldamers Journal Paper, Thomas Edwards,Andrew Wilson, Amino Acids DOI: 10.1007/s00726-011-0880-8
March 2011 Inhibition of Histone Demethylases by 4-Carboxy-2,2-Bipyridyl Compounds Journal Paper, Chang,Oliver King,Antony Tumber, Woon,Tom Heightman,Michael McDonough, Schofield, Rose, ChemMedChem 6 DOI: 10.1002/cmdc.201100026
March 2011 Benzimidazole Inhibitors Induce a DFG-Out Conformation of Never in Mitosis Gene A-Related Kinase 2 (Nek2) without Binding to the Back Pocket and Reveal a Nonlinear Structure&#8722;Activity Relationship Journal Paper, Richard Bayliss,C Mas-Droux,Rob van Montfort, J Med Chem. 54 PMID: 21366329
March 2011 Structural analysis of a novel class of R-M controller proteins: C.Csp231I from Citrobacter sp. RFL231 Journal Paper, John McGeehan, Streeter, Thresh, Taylor, Shevtsov,Geoff Kneale, Journal of Molecular Biology DOI: 10.1016/j.jmb.2011.03.033
March 2011 The structure of Bacillus subtilis SP[beta] prophage dUTPase and its complexes with two nucleotides Journal Paper, Javier García-Nafría,Maria Harkiolaki,R Persson,Mark Fogg,Keith Wilson, Biological Crystallography 67 DOI: 10.1107/S0907444911003234
March 2011 Understanding small-molecule binding to MDM2: Insights into structural effects of isoindolinone inhibitors from NMR spectroscopy Journal Paper, Christiane Riedinger,Martin Noble, Wright, Mulks, Hardcastle,Jane Endicott, McDonnell , Chemical Biology and Drug Design DOI: 10.1111/j.1747-0285.2011.01091.x
March 2011 Structure of mammalian AMPK and its regulation by ADP Journal Paper, Bing Xiao,Matthew J. Sanders,Elizabeth Underwood,Richard Heath,Faith V. Mayer,David Carmena,Chun Jing,Philip A. Walker,John F. Eccleston,Lesley F. Haire,Peter Saiu,Steven A. Howell,Rein Aasland,Stephen R. Martin,David Carling,Steven J. Gamblin, Nature 472 DOI: 10.1038/nature09932 PMID: 21399626
February 2011 Determinants of laminin polymerization revealed by the structure of the &#945;5 chain amino-terminal region Journal Paper, Sadaf-Ahmahni Hussain,Federico Carafoli,Erhard Hohenester, EMBO reports DOI: 10.1038/embor.2011.3
February 2011 Structures of the TetR-like simocyclinone efflux pump repressor, SimR, and the mechanism of ligand-mediated derepression Journal Paper, Tung Le,Clare Stevenson,Hans-Peter Fiedler,Anthony Maxwell,David Lawson,Mark Buttner, Journal of Molecular Biology DOI: 10.1016/j.jmb.2011.02.035
February 2011 Crystal Structure of R120G Disease Mutant of Human &#945;B-Crystallin Domain Dimer Shows Closure of a Groove Journal Paper, A. Clark, Naylor,Claire Bagneris,Nicholas Keep, Slingsby, Journal of Molecular Biology 408 DOI: 10.1016/j.jmb.2011.02.020
February 2011 The structure and function of an arabinan-specific alpha-1,2-arabinofuranosidase identified from screening the activities of bacterial GH43 glycoside hydrolases Journal Paper, Alan Cartmell,Lauren McKee,Maria Pena,Johan Larsbrink,Harry Brumer,Satoshi Kaneko,Hatomi Ichinose,Rick Lewis,Anders Vikso-Neilson,Harry Gilbert,Jon Marles-Wright, Journal of Biological Chemistry DOI: 10.1074/jbc.M110.215962
February 2011 Structural basis for the subunit assembly of the anaphase-promoting complex Journal Paper, Anne Schreiber,Florian Stengel,Ziguo Zhang,Radoslav I. Enchev,Eric H. Kong,Edward P. Morris,Carole Robinson,Paula C. A. da Fonseca,David Barford, Nature 470 DOI: 10.1038/nature09756 PMID: 21307936
February 2011 Structures of APC/C(Cdh1) with substrates identify Cdh1 and Apc10 as the D-box co-receptor Journal Paper, David Barford, Schreiber, da Fonseca,Eric Kong,Ziguo Zhang, Williams, Morris, Nature 470 PMID: 21107322
February 2011 Structural basis of ligand specificity in the human pentraxins, C-reactive protein and serum amyloid P component Journal Paper, Halina Mikolajek,Simon Kolstoe,Valerie Pye,Palma Mangione,Mark Pepys,S Wood, Journal of Molecular Recognition 24 (2) DOI: 10.1002/jmr.1090
February 2011 Structural basis for engagement by complement factor H of C3b on a self surface Journal Paper, Hugh P Morgan,Christoph Q Schmidt,Mara Guariento,Bärbel S Blaum,Dominic Gillespie,Andrew P Herbert,David Kavanagh,Haydyn D T Mertens,Dmitri I Svergun,Conny M Johansson,Dušan Uhrín,Paul N Barlow,Jonathan P Hannan, Nature Structural & Molecular Biology 18 DOI: 10.1038/nsmb.2018
February 2011 Crystal Structure of Glucansucrase from the Dental Caries Pathogen Streptococcus mutans Journal Paper, Keisuke Ito ,Tatsuro Shimamura, Weyand, Kawarasaki, Misaka, Abe,Takuya Kobayashi,Alex Cameron,So Iwata, Journal of Molecular Biology DOI: 10.1016/j.jmb.2011.02.028
February 2011 Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response Journal Paper, Maruf M U Ali,Tina Bagratuni,Emma L Davenport,Piotr R Nowak,M Cris Silva-Santisteban,Anthea Hardcastle,Craig McAndrews,Martin G Rowlands,Gareth J Morgan,Wynne Aherne,Ian Collins,Faith E Davies,Laurence H Pearl, The EMBO Journal 30 DOI: 10.1038/emboj.2011.18 PMID: 21317875
February 2011 Conformational Flexibility of the Ligand-Binding Domain Dimer in Kainate Receptor Gating and Desensitization Journal Paper, Naushaba Nayeem,Olga Mayans,Tim Green, Journal of Neuroscience 31 (8) DOI: 10.1523/&#8203;JNEUROSCI.4771-10.2011
January 2011 Crystal structure of a prokaryotic homologue of the mammalian oligopeptide-proton symporters, PepT1 and PepT2. Journal Paper, Simon Newstead ,David Drew,Alexander Cameron,Vincent Postis,Xiaobing Xia,Philip Fowler,Jean Ingram,Elisabeth Carpenter,Mark Sansom,Michael McPherson,Stephen Baldwin,So Iwata, The EMBO Journal PMID: 21131908
January 2011 Crystal structure of DNA polymerase III &#946; sliding clamp from Mycobacterium tuberculosis Journal Paper, Wen-Jun Gui,Shi-Qiang Lin,Yuan-Yuan Chen,Xian-En Zhang,Li-Jun Bi,Tao Jiang, Biochemical and Biophysical Research Communications DOI: 10.1016/j.bbrc.2011.01.027
January 2011 Structural and functional characterization of Pseudomonas aeruginosa CupB chaperones. Journal Paper, Xun Cai,Rui Wang,Alain Filloux,Gabriel Waksman,Goyu Meng, PLoS One DOI: 10.1371/journal.pone.0016583
January 2011 Crystallization and initial crystallographic analysis of AafA: the major adhesive subunit of the enteroaggregative Journal Paper, Yi Yang,James A. Garnett,Stephen Matthews, Acta Crystallographica Section F Structural Biology and Crystallization Communications 67 DOI: 10.1107/S1744309111001412
January 2011 Importance of single molecular determinants in the fidelity of expanded genetic codes Journal Paper, A. K. Antonczak,Z. Simova,I. T. Yonemoto,M. Bochtler,A. Piasecka,H. Czapinska,A. Brancale,E. M. Tippmann, Proceedings of the National Academy of Sciences 108 DOI: 10.1073/pnas.1012276108
January 2011 How the biotin-streptavidin interaction was made even stronger: investigation via crystallography and a chimeric tetramer Journal Paper, Claire Chivers,Apurba Koner,Ed Lowe,Mark Howarth, Biochemical Journal DOI: 10.1042/BJ20101593
January 2011 The structure of human complement factor I Conference Paper, Pietro Roversi,Steven Johnson, null
January 2011 Structure and mechanism of the chalcogen detoxifying protein TehB from Escherichia coli Journal Paper, Hassan Choudhury,Alex Cameron,So Iwata,Konstantinos Beis, Biochemical Journal DOI: 10.1042/BJ20102014
January 2011 Structure-Based Design of Potent and Selective 2-(Quinazolin-2-yl)phenol Inhibitors of Checkpoint Kinase 2 Journal Paper, John J. Caldwell,Emma J. Welsh,Cornelis Matijssen,Victoria E. Anderson,Laurent Antoni,Kathy Boxall,Frederique Urban,Angela Hayes,Florence I. Raynaud,Laurent J. M. Rigoreau,Tony Raynham,G. Wynne Aherne,Laurence H. Pearl,Antony W. Oliver,Michelle D. Garrett,Ian Collins, Journal of Medicinal Chemistry 54 DOI: 10.1021/jm101150b PMID: 21186793
January 2011 Dissecting the mechanism of oxygen trafficking in a metalloenzyme Journal Paper, Mark Smith,Peter Knowles,Michael McPherson,Arwen Pearson, Faraday Discussions 148 DOI: 10.1039/c005054g
January 2011 Extending the usability of the phasing power of diselenide bonds: SeCys SAD phasing of CsgC using a non-auxotrophic strain. Journal Paper, Paula Salgado,Jon Taylor,Ernesto Cota-Segura,Steve Matthews, Acta Crystallogr D Biol Crystallogr 67 DOI: 10.1107/S0907444910042022
January 2011 Phosphotyrosine recognition by the Raf Kinase Inhibitor Protein Journal Paper, Philip Simister,Nick Burton,Leo Brady, Forum on Immunopathological Diseases and Therapeutics 2(1) DOI: 10.1615/ForumImmunDisTher.v2.i1.70
January 2011 Expression, purification, crystallization and preliminary X-ray analysis of wild-type and of an active-site mutant of glyceraldehyde-3-phosphate dehydrogenase from Campylobacter jejuni Journal Paper, David Tourigny,Paul Elliott,J Edgell,G Hudson,Peter Moody, Acta Crystallographica Section F Structural Biology and Crystallization Communications 67 (1) DOI: 10.1107/S1744309110044465
December 2010 Structural and biochemical characterization of Mycobacterium tuberculosis CYP142: evidence for multiple cholesterol 27-hydroxylase activities in a human pathogen Journal Paper, M Driscoll,Kirsty J. McLean,Colin Levy,Nathalia Mast,Irina A Pikuleva,David Leys,Pierre Lafite,Stephen Rigby,Andrew Munro, Journal of Biological Chemistry 285 DOI: 10.1074/jbc.M110.164293 PMID: 20889498
December 2010 Delineation of the complement receptor type 2-C3d complex by site-directed mutagenesis and molecular docking Journal Paper, Jonathan Hannan,Craig Shaw,Michael Storek,Kendra Young,James Kovacs, Journal of Molecular Biology DOI: 10.1016/j.jmb.2010.10.005 PMID: 20951140
December 2010 Structural and Mechanistic Studies on &#947;-Butyrobetaine Hydroxylase Journal Paper, Ivanhoe K.H. Leung,Tobias Krojer,Grazyna Kochan,Luc Henry,Frank von Delft,Timothy D.W. Claridge,Udo Oppermann,Michael McDonough,Christopher J. Schofield, Chemistry & Biology 17 DOI: 10.1016/j.chembiol.2010.09.016
December 2010 Stabilization of mutant p53 via alkylation of cysteines and effects on DNA binding Journal Paper, Joel Kaar,Nicolas Basse,Andreas Christian Joerger,Elaine Stephens,Trevor Rutherford,Alan Fersht, PROTEIN SCIENCE 19 DOI: 10.1002/pro.507
December 2010 Structural basis of poly(ADP-ribose) recognition by the multizinc binding domain of checkpoint with forkhead-associated and RING Domains (CHFR) Journal Paper, Richard Bayliss,Jasmeen Oberoi,M Richards,N Brown, Journal of Biological Chemistry 285 PMID: 20880844
December 2010 The crystal structure of the ubiquitin-like (UbL) domain of human homologue A of Rad23 (hHR23A) protein Journal Paper, Y. W. Chen,T. Tajima,S. Agrawal, Protein Engineering Design and Selection 24 DOI: 10.1093/protein/gzq084
December 2010 Structural and mechanistic studies on Gamma-butyrobetaine hydroxylase. Journal Paper, Leung,Tobias Krojer,Grazyna Kochan, Henry,Frank von Delft,Timothy Claridge,Udo Oppermann,Michael McDonough, Schofield, CHEMISTRY & BIOLOGY 17 DOI: 10.1016/j.chembiol.2010.09.01
December 2010 Cloning, purification and preliminary crystallographic analysis of cobalamin methyltransferases from Rhodobacter capsulatus Journal Paper, Arefeh Seyedarabi,M-T Hutchison,T To,E Deery,A Brindley,M Warren,Richard Pickersgill, Acta Crystallographica Section F Structural Biology and Crystallization Communications 66 (12) DOI: 10.1107/S1744309110042910
December 2010 Expression, purification, crystallization and initial X-ray diffraction analysis of thiol peroxidase from Yersinia pseudotuberculosis Journal Paper, Mads Gabrielsen,Caroline Zetterström,Dai Wang,Katherine Beckham,Mikael Elofsson, Isaacs,Andrew Roe, Acta Crystallographica Section F Structural Biology and Crystallization Communications 66 (10) DOI: 10.1107/S1744309110039679
November 2010 Aminopyrazine inhibitors binding to an unusual inactive conformation of the mitotic kinase Nek2: SAR and structural characterization. Journal Paper, Richard Bayliss,C Mas-Droux,Rob van Montfort, J Med Chem. 53 PMID: 20936789
November 2010 Shigella flexneri Spa15 Crystal Structure Verified in solution by Double Electron Electron Resonance Journal Paper, James Lillington,Janet E. Lovett,Steven Johnson,Pietro Roversi,Christine Timmel,Susan Lea, Journal of Molecular Biology DOI: 10.1016/j.jmb.2010.10.053
November 2010 The mechanism of retroviral integration from X-ray structures of its key intermediates. Journal Paper, Goedele Maertens,Stephen Hare,Peter Cherepanov, Nature 468 DOI: 10.1038/nature09517
November 2010 Distal-to-Proximal NO Conversion in Hemoproteins: The Role of the Proximal Pocket Journal Paper, Mike Hough,Svetlana Antonyuk,Sonia Barbieri,Neil Rustage,Alison McKay,Amy Servid,Robert Eady,Colin Andrews,Samar Hasnain, Journal of Molecular Biology DOI: 10.1016/j.jmb.2010.10.035
November 2010 Crystal structure of TtgV in complex with its DNA operator reveals a general model for cooperative DNA binding of tetrameric gene regulators. Journal Paper, Duo Lu,Sandy Fillet, Meng,Yilmaz Alguel,Patrick Kloppsteck, Bergeron, Krell, Gallegos, Ramos,Xiaodong Zhang, Genes Dev 24(22) DOI: 10.1101/gad.603510
November 2010 Structure, function and mechanism of the anaphase promoting complex (APC/C) Journal Paper, David Barford, Q Rev Biophys 22 PMID: 21092369
October 2010 Loop-Sheet Mechanism of Serpin Polymerization Tested by Reactive Center Loop Mutations Journal Paper, Massayuki Yamasaki,Timothy Sendall, Harris,Giles Lewis,James Huntingdon, Journal of Biological Chemistry 285 DOI: 10.1074/jbc.M110.156042
October 2010 A redox switch in angiotensinogen modulates angiotensin release Journal Paper, Aiwu Zhou,Robin Carrell,Michael Murphy,Zhenquan Wei,Yahui Yan,Peter Stanley,Penelope Stein,Fiona Broughton Pipkin,Randy Read, Nature DOI: 10.1038/nature09505
October 2010 Chemical genetics and cereal starch metabolism: structural basis of the non-covalent and covalent inhibition of barley b-amylasew Journal Paper, Martin Rejzek,Clare Stevenson,Andrew Southard,Duncan Stanley,Kay Denyer,Alison Smith,Mike Naldrett,David Lawson,Robert Field, Molecular Biosystems DOI: 10.1039/c0mb00204f
October 2010 Structure and Mechanism of the Magnesium-Independent Aromatic Prenyltransferase CloQ from the Clorobiocin Biosynthetic Pathway Journal Paper, Ute Metzger,Sascha Keller,Clare Stevenson,Lutz Heide,David Lawson, Journal of Molecular Biology DOI: 10.1016/j.jmb.2010.09.067
October 2010 Structural and functional studies on the extracellular domain of BST2/tetherin in reduced and oxidized conformations Journal Paper, H. L. Schubert,Q. Zhai,V. Sandrin,D. M. Eckert,M. Garcia-Maya,L. Saul,W. I. Sundquist,Roberto Steiner,C. P. Hill, Proceedings of the National Academy of Sciences 107 DOI: 10.1073/pnas.1008206107
October 2010 Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance Journal Paper, Stephen Hare,Ann Vos,Reginald Clayton,Jan Thuring,Maxwell Cummings,Peter Cherepanov, Proceedings of the National Academy of Sciences DOI: 10.1073/pnas.1010246107
October 2010 Crystal structures of penicillin-binding protein 3 from Pseudomonas aeruginosa: Comparison of native and antibiotic-bound forms Journal Paper, Sarah Sainsbury,Louise Bird,Vincenzo Rao,Sharon M Shepherd,Dave Stuart,William Hunter,Raymond Owens,Jingshan Ren, Journal of Molecular Biology DOI: 10.1016/j.jmb.2010.10.024
October 2010 Filament structure of bacterial tubulin homologue TubZ Journal Paper, Christopher Aylett,Qing Wang,Kate Michie,Linda Amos,Jan Lowe, Proceedings of the National Academy of Sciences DOI: 10.1073/pnas.1010176107
September 2010 The APC/C subunit Cdc16/Cut9 is a contiguous tetratricopeptide repeat superhelix with a homo-dimer interface similar to Cdc27 Journal Paper, Ziguo Zhang,Kiran Kulkarni,Sarah Hanrahan,Andrew Thompson,David Barford, The EMBO Journal DOI: 10.1038/emboj.2010.247
September 2010 Structural Insights into Substrate Specificity in Variants of N-Acetylneuraminic Acid Lyase Produced by Directed Evolution Journal Paper, Ivan Campeotto,Amanda Bolt,Thomas Harman ,Caitriona Dennis,Chi Hung Trinh,Simon Phillips, Nelson,Arwen Pearson,Alan Berry, Journal of Molecular Biology DOI: 10.1016/j.jmb.2010.08.008
September 2010 The N domain of human angiotensin-I converting enzyme: the role of N-glycosylation and the crystal structure in complex with an N domain specific phosphinic inhibitor RXP407 Journal Paper, Colin Anthony,Hazel Corradi,Sylva Schwager,Dimitris Georgiadis,Vincent Dive,Ravi Acharya,Edward Sturrock, Journal of Biological Chemistry DOI: 10.1074/jbc.M110.167866
September 2010 TolA Modulates the Oligomeric Status of YbgF in the Bacterial Periplasm Journal Paper, Anna Marie Krachler,Amit Sharma,Anna Cauldwell,Grigorios Papadakos,Colin Kleanthous, Journal of Molecular Biology DOI: 10.1016/j.jmb.2010.08.050
September 2010 Stabilization of mutant p53 via alkylation of cysteines and effects on DNA binding Journal Paper, Joel Kaar,Nicolas Basse,Andreas Christian Joerger,Elaine Stephens,Trevor Rutherford,Alan Fersht, Protein Science DOI: 10.1002/pro.507
September 2010 Structures of the Human GTPase MMAA and Vitamin B12-dependent Methylmalonyl-CoA Mutase and Insight into Their Complex Formation Journal Paper, Sean Froese, Kochan, Muniz, Wu, Gileadi, Ugochukwu, Krysztofinska, Gravel, Oppermann, Yue, Journal of Biological Chemistry 285 DOI: 10.1074/jbc.M110.177717
September 2010 The structure of the FnIII Tandem A77-A78 points to a periodically conserved architecture in the myosin-binding region of titin Journal Paper, Olga Mayans, Journal of Molecular Biology 401 PMID: 20542041
September 2010 Near-atomic resolution analysis of BipD, a component of the type III secretion system of Burkholderia pseudomallei Journal Paper, M Pal,Peter Erskine,R Gill,S Wood,R Cooper, Acta Crystallographica Section F Structural Biology and Crystallization Communications 66 (9) DOI: 10.1107/S1744309110026333
September 2010 The structural basis for catalysis and substrate specificity of a rhomboid protease Journal Paper, Kutti Vinothkumar,Kvido Strisovsky, Andreeva,Yonka Christova,Steven Verhelst, Freeman, The EMBO Journal DOI: 10.1038/emboj.2010.243
August 2010 Crystal structure of MexZ, a key repressor responsible for antibiotic resistance in Pseudomonas aeruginosa Journal Paper, Yilmaz Alguel,Duo Lu,Nick Quade, Sauter,Xiaodong Zhang, Journal of Structural Biology 172(3) PMID: 20691272
August 2010 The Corynebacterium glutamicum aconitase repressor: scratching around for crystals Journal Paper, Javier García-Nafría,Meike Baumgart,Michael Bott,Anthony Wilkinson,Keith Wilson, Acta Crystallographica Section F Structural Biology and Crystallization Communications 66(9) DOI: 10.1107/S1744309110029015
August 2010 The Structure of CyanoP at 2.8Å: Implications for the evolution and function of the PsbP subunit of Photosystem II Journal Paper, Franck Michoux,Kenji Takasaka,Marko Boehm,Peter Nixon,James W Murray, Biochemistry DOI: 10.1021/bi1011145
August 2010 Visualizing the Metal-Binding Versatility of Copper Trafficking Sites Journal Paper, Adriana Badarau,Susan Firbank,Andrew McCarthy,Mark Banfield,Christopher Dennison, Biochemistry 49 DOI: 10.1021/bi101064w PMID: 20726513
July 2010 A Novel Mechanism for Azoreduction Journal Paper, Anthony Ryan,Nicola Laurieri,Isaac Westwood,Chan-Ju Wang,Ed Lowe, Sim, Journal of Molecular Biology 400 DOI: 10.1016/j.jmb.2010.04.023
July 2010 Structural origins of pH dependent chemical shifts in the B1 domain of protein G Journal Paper, Vicky Green,Patrick Baker,Mike Williamson,Jennifer Tomlinson, Proteins 78 DOI: 10.1002/prot.22825
July 2010 Functional Dissection of a Trigger Enzyme: Mutations of the Bacillus subtilis Glutamate Dehydrogenase RocG That Affect Differentially Its Catalytic Activity and Regulatory Properties Journal Paper, Katrin Gunka,Joseph A Newman,Fabian Commichau,Christina Herzberg,Cecilia Rodriguez,Lorraine Hewitt,Rick Lewis,Jorg Stulke, Journal of Molecular Biology 400 (4) DOI: 10.1016/j.jmb.2010.05.055
June 2010 Crystal structures of Bacillus subtilis Lon protease. Journal Paper, R Duman,Jan Lowe, Journal of Molecular Biology 401 PMID: 20600124
June 2010 A Large-Scale Conformational Change Couples Membrane Recruitment to Cargo Binding in the AP2 Clathrin Adaptor Complex Journal Paper, Jackson,Bernie Kelly,Airlie McCoy,Thomas Gaffry,Leo James,Brett Collins,Stefan Höning,Phil Evans,David Owen, Cell DOI: DOI 10.1016/j.cell.2010.05.006
June 2010 Isolation and characterisation of EfeM, a periplasmic component of the putative EfeUOBM iron transporter of Pseudomonas syringae pv. syringae Journal Paper, Mohan Rajasekaran,Susan Mitchell, Gibson,Rohanah Hussain,Giuliano Siligardi,Simon Andrews,Kim Watson, Biochemical and Biophysical Research Communications DOI: 10.1016/j.bbrc.2010.06.072
June 2010 Specificity of Polysaccharide Use in Intestinal Bacteroides Species Determines Diet-Induced Microbiota Alterations Journal Paper, Erica Sonnenburg,Hongjun Zheng,Payal Joglekar,Steven Higginbottom,Susan Firbank,David Bolam,Justin Sonnenburg, Cell 141 (7) DOI: 10.1016/j.cell.2010.05.005
June 2010 Structural Basis of Gate-DNA Breakage and Resealing by Type II Topoisomerases Journal Paper, Ivan Laponogov,Xiao-Su Pan,Dennis A. Veselkov,Katherine McAuley,L. Mark Fisher,Mark R. Sanderson,Art J. Lustig, PLoS ONE 5 DOI: 10.1371/journal.pone.0011338
May 2010 High-Resolution Crystal Structures of Drosophila melanogaster Angiotensin-Converting Enzyme in Complex with Novel Inhibitors and Antihypertensive Drugs Journal Paper, Akif Mohd,Dimitris Georgiadis,Aman Mahajan,Vincent Dive,Edward Sturrock,R Elwyn Isaac,Ravi Acharya, Journal of Molecular Biology 400 DOI: doi:10.1016/j.jmb.2010.05.024
May 2010 The Biomechanical Response of Normal and Glaucoma Human Sclera Poster, Baptiste Coudrillier,Kristin Myers,Harry Quigley,Craig Boote,Thao Nguyen, null
May 2010 Posterior scleral collagen architecture in normal and glaucoma human eyes, as determined using wide-angle X-ray scattering. Poster, Craig Boote,Thomas Sorensen,Baptiste Coudrillier,Kristin Myers,Keith Meek,Harry Quigley,Thao Nguyen, null
May 2010 CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells Journal Paper, Karima Bettayeb,Diane Baunbeck,Claire Delehouze,Nadege Loaec,Alison Hole,Sonja Baumli,Jane Endicott,Setha Douc-Rasy,Jean Benard,Nassim Oumata,Herve Galons, Meijer, Genes and Cancer DOI: 10.1177/1947601910369817
May 2010 Features critical for membrane binding revealed by DivIVA crystal structure Journal Paper, Maria Oliva,Sven Halbedel,Stefan Freund,Pavel Dutow,Thomas Leonard,Dmitry Veprintsev,Leendert Hamoen,Jan Lowe, The EMBO Journal 29 DOI: 10.1038/emboj.2010.99
May 2010 Structural Insights into the Binding of VEGF-B by VEGFR-1D2: Recognition and Specificity Journal Paper, Shalini Iyer,Paula Darley,Ravi Acharya, Journal of Biological Chemistry DOI: 10.1074/jbc.M110.130658
April 2010 Structural homology between the C-terminal domain of the PapC usher and its plug. Journal Paper, Bradley Ford,Ana Toste Rego,Timothy Ragan,Jerome Pinkner,Karen Dodson,Paul Driscoll,Scott Hultgren,Gabriel Waksman, Journal of Bacteriology 10.1128/JB.01677-09
April 2010 Domain cross-talk during effector binding to the multidrug binding TTGR regulator Journal Paper, Craig Daniels, Daddaoua,Duo Lu,Xiaodong Zhang, Ramos, Journal of Biological Chemistry 285(28) DOI: 10.1074/jbc.M110.113282
April 2010 Glutamate-haem ester bond formation is disfavoured in flavocytochrome P450 BM3: characterization of glutamate substitution mutants at the haem site of P450 BM3 Journal Paper, Hazel Girwan,Colin Levy,P Williams,K Fisher,Myles Cheesman,Stephen Rigby,David Leys,Andrew Munro, Biochemical Journal 427 PMID: 20180779
April 2010 The structure of the FYR domain of transforming growth factor beta regulator 1 Journal Paper, Maria Garc&#305;´a-Alai,Mark Allen,Andreas Christian Joerger,Mark Bycroft, PROTEIN SCIENCE 19 DOI: 10.1002/pro.404 PMID: 20506279
April 2010 With phases: how two wrongs can sometimes make a right Journal Paper, Pietro Roversi,Steven Johnson,Susan Lea, Acta Crystallographica Section D Biological Crystallography 66 DOI: 10.1107/S0907444909048112 PMID: 20382995
April 2010 Crystallization and preliminary X-ray analysis of a D-alanyl-D-alanine ligase (EcDdlB) from Escherichia coli. Journal Paper, Sarah Batson,Dean Rea,Vilmos Fulop,David Roper, Acta Crystallographica Section F Structural Biology and Crystallization Communications 66 DOI: 10.1107/S1744309110003970
April 2010 Generation and Characterization of a Chimeric Rabbit/Human Fab for Co-Crystallization of HIV-1 Rev Journal Paper, Stephen Stahl, Watts, Rader, Dimattia, Mage, Palmer, Kaufman,Jonathan Grimes,Dave Stuart, Steven, Wingfield, Journal of Molecular Biology 397 DOI: 10.1016/j.jmb.2010.01.061
April 2010 Molecular Structure of the N-terminal Domain of the APC/C Subunit Cdc27 Reveals a Homo-dimeric Tetratricopeptide Repeat Architecture Journal Paper, Ziguo Zhang,Mark Roe,Marie Diogon,Eric Kong,Hicham El Alaoui,David Barford, Journal of Molecular Biology 397 (5) DOI: 10.1016/j.jmb.2010.02.045
March 2010 Implications of the HIV-1 Rev dimer structure at 3.2 Å resolution for multimeric binding to the Rev response element Journal Paper, Mike DiMattia, Watts,Stephen Stahl,Christoph Rader,Paul Wingfield,Dave Stuart,Alisdair Steven,Jonathan Grimes, Proceedings of the National Academy of Sciences 107 DOI: 10.1073/pnas.0914946107 PMID: 20231488
March 2010 Crystal structure of the LasA virulence factor from Pseudomonas aeruginosa: substrate specificity and mechanism of M23 metallopeptidases. Journal Paper, Jim Spencer,Loretta Murphy,Rebecca Conners,Richard Sessions,Steven Gamblin, Journal of Molecular Biology 396(4) PMID: 20026068
March 2010 Collagen and mature elastic fibre organisation as a function of depth in the human cornea and limbus. Journal Paper, Christina Kamma-Lorger,Craig Boote,Sally Hayes,Julian Moger,Manfred Burhammer,Carlo Knupp,Andrew Quantock,Thomas Sorensen,Emmanuella DiCola,Nick White,Keith Meek,Robert Young, Journal of Structural Biology 169 PMID: 19914381
February 2010 Structural basis for the interaction between yeast SAGA complex components Sgf11 and Sus1. Journal Paper, Andrew Ellisdon,Divyang Jani, Kohler,Ed Hurt, Stewart, Journal of Biological Chemistry 285 DOI: 10.1074/jbc.M109.070839 PMID: 20007317
February 2010 Structural insight into M-band assembly and mechanics from the titin-obscurin-like-1 complex Journal Paper, S. Pernigo,A. Fukuzawa,M. Bertz,M. Holt,M. Rief,R. A. Steiner,M. Gautel, Proceedings of the National Academy of Sciences 107 DOI: 10.1073/pnas.0913736107
February 2010 Reengineering orthogonally selective riboswitches Journal Paper, N Dixon,J Duncan,T Geerlings, Dunstan,J McCarthy,David Leys,Jason Micklefield, Proceedings of the National Academy of Sciences 107 PMID: 20133756
February 2010 Analysis of the Reaction Coordinate of &#945;- Journal Paper, Alicia Lammerts Van Bueren,Jennifer Fayers-Kerr,Bo Luo,Yongmin Zhang,Matthieu Sollogoub,Yves Ble&#769;riot,Carme Rovira,Gideon Davies, Journal of the American Chemical Society 132 DOI: 10.1021/ja908908q
February 2010 Mutations in an avian IgY-Fc fragment reveal the locations of monocyte Fc receptor binding sites Journal Paper, Alexander I. Taylor,Brian J. Sutton,Rosaleen A. Calvert, Developmental & Comparative Immunology 34 DOI: 10.1016/j.dci.2009.08.012 PMID: 19733585
January 2010 Structural basis for cofactor-independent dioxygenation of N-heteroaromatic compounds at the  / -hydrolase fold Journal Paper, Roberto Steiner,H. J. Janssen,P. Roversi,A. J. Oakley,S. Fetzner, Proceedings of the National Academy of Sciences 107 DOI: 10.1073/pnas.0909033107
January 2010 Retroviral intasome assembly and inhibition of DNA strand transfer Journal Paper, Saumya Shree Gupta,Eugene Valkov,Alan Engelman,Peter Cherepanov,Stephen Hare, Nature DOI: 10.1038/nature08784
January 2010 Biocatalysis with thermostable enzymes: structure and properties of a thermophilic 'ene'-reductase related to old yellow enzyme Journal Paper, B Adalbjörnsson,H Toogood,A Fryszkowska, Pudney,Thomas Jowitt,David Leys,Nigel Scrutton, Chembiochem 11 PMID: 19943268
January 2010 Structural Insights into the Prereaction State of Pyruvate Decarboxylase from Zymomonas mobilis Journal Paper, Pei, Erixon,Ben Luisi, Leeper, Biochemistry 49 DOI: 10.1021/bi901864j
January 2010 Molecular basis of factor IXa recognition by heparin-activated antithrombin revealed by a 1.7-angstrom structure of the ternary complex Journal Paper, Daniel Johnson, Langdown, Huntington, Proceedings of the National Academy of Sciences 107 DOI: 10.1073/pnas.0910144107
January 2010 The K5 Lyase KflA Combines a Viral Tail Spike Structure with a Bacterial Polysaccharide Lyase Mechanism Journal Paper, Thompson, Pourhossein, Waterhouse, Hudson,Marie Goldrick,Jeremy Derrick,Ian Roberts, Journal of Biological Chemistry 285 DOI: 10.1074/jbc.M110.127571
January 2010 Crystallization and preliminary X-ray analysis of a glucansucrase from the dental caries pathogen Streptococcus mutans Journal Paper, Keisuke Ito , Ito, Shimamura, Kawarasaki, Abe, Misaka, Kobayashi,So Iwata, Acta Crystallographica Section F Structural Biology and Crystallization Communications 66 DOI: 10.1107/S1744309110029714
January 2010 Analysis of the reaction coordinate of alpha-L-fucosidases: a combined structural and quantum mechanical approach. Journal Paper, Alicia Lammerts Van Bueren, Ardevol, Fayers-Kerr, Luo, Zhang, Sollogoub, Bleriot, Rovira, Davies, Journal of the American Chemical Society 132 DOI: 10.1021/ja908908q
January 2010 Visualizing the Reaction Coordinate of an O-GlcNAc Hydrolase Journal Paper, He, Macauley, Stubbs, Vocadlo, Davies, Journal of the American Chemical Society 132 DOI: 10.1021/ja9086769
January 2010 The P110D Structure: Mechanisms for Selectivity and Potency of New Pi(3)K Inhibitors Journal Paper, Alex Bernt,Simon Miller,Olusegun Williams,Daniel Le,Benjamin Houseman,Joseph Pacold,Fabrice Gorrec,Wai-Ching Hon,Yi Liu,Christian Rommel,Pascale Gaillard,Thomas Rückle,Matthias Schwarz,Kevan Shokat,Jeffrey Shaw,Roger Williams, Nature Chemical Biology 6 DOI: 10.1038/nchembio.293
January 2010 Large-scale Domain Dynamics and Adenosylcobalamin Reorientation Orchestrate Radical Catalysis in Ornithine 4,5-Aminomutase Journal Paper, Wolthers,Colin Levy,Nigel Scrutton,David Leys, Journal of Biological Chemistry 285 DOI: 10.1074/jbc.M109.068908
January 2010 Implications for the active form of human insulin based on the structural convergence of highly active hormone analogues Journal Paper, Jiracek, Zakova, Antolikova, Watson,Johan Turkenburg, Dodson, Brzozowski, Proceedings of the National Academy of Sciences 107 DOI: 10.1073/pnas.0911785107
December 2009 Crystallographic Insight Into Collagen Recognition by Discoidin Domain Receptor 2 Journal Paper, F Carafoli,D Bihan,S Stathopoulos,A Konitsiotis ,M Kvansakul,R Farndale,B Leitinger ,E Hohenester, Structure 17 (12) DOI: 10.1016/j.str.2009.10.012
December 2009 Evidence To Support the Hypothesis That Promoting Vibrations Enhance the Rate of an Enzyme Catalyzed H-Tunneling Reaction Journal Paper, Pudney, Hay, Levy, Pang, Sutcliffe,David Leys,Nigel Scrutton, Journal of the American Chemical Society 131 DOI: 10.1021/ja908469m
December 2009 Structure of the outer membrane complex of a type IV secretion system. Journal Paper, Vidya Chandran,Remi Fronzes,Stephane Duquerroy,Nora Cronin,Jorge Navaza,Gabriel Waksman, Nature DOI: 10.1038/nature08588.
November 2009 Crystal Structure of a Mucus-binding Protein Repeat Reveals an Unexpected Functional Immunoglobulin Binding Activity Journal Paper, D. A. MacKenzie,Louise Tailford,A. M. Hemmings,N. Juge, Journal of Biological Chemistry 284 DOI: 10.1074/jbc.M109.040907
November 2009 Synthesis and Biological Evaluation of Coumarin-Based Inhibitors of NAD(P)H: Quinone Oxidoreductase-1 (NQO1) Journal Paper, Nolan, Doncaster, Dunstan, Scott, Frenkel, Siegel, Ross, Barnes, Levy, Whitehead, Stratford, Bryce,David Leys, Journal of Medicinal Chemistry 52 DOI: 10.1021/jm9011609
October 2009 Structural Evolution of P53, P63 and P73: Implication for Heterotetramer Formation Journal Paper, Sridharan Rajagopalan,Eviata Najan,Dmitry Veprintsev,Carole Robinson,Alan Fersht,Andreas Christian Joerger, Proceedings of the National Academy of Sciences DOI: 10.1073/pnas.0905867106
October 2009 Crystal structure of protein Z-dependent inhibitor complex shows how protein Z functions as a cofactor in the membrane inhibition of factor X. Journal Paper, Zhenquan Wei, W Carrell,Aiwu Zhou, Blood 114 DOI: 10.1182/blood-2009-04-210021.
October 2009 Structures of receptor complexes formed by hemagglutinins from the Asian Influenza pandemic of 1957 Journal Paper, David Stevens,Lesley Haire,Phil Walker,Peter Coombs,Rupert Russell,John Skehel,Steven Gamblin, Liu, Proceedings of the National Academy of Sciences 106 (40) DOI: 10.1073/pnas.0906849106
October 2009 Structural comparison of two CSPG-binding DBL domains from the VAR2CSA protein important in malaria during pregnancy Journal Paper, Pongsak Khunrae, Philip,Duncan Bull,Matthew Higgins, Journal of Molecular Biology 393 (1) PMID: 19695262
October 2009 Structural Plasticity of Eph-Receptor A4 Facilitates Cross-Class Ephrin Signalling Journal Paper, Joanne Nettleship, Nahid Rahman-Huq,Raymond Owens,Dave Stuart,Yvonne Jones,Alexandru Aricescu,Thomas Bowden,Christian Siebold, Structure 17 (10) DOI: 10.1016/j.str.2009.07.018
October 2009 Structure-based mechanism of CMP-Kdo synthetase: convergent evolution of a sugar activating enzyme with DNA-/RNA-polymerases Journal Paper, Derren Heyes,Ian Roberts,Marie Goldrick,Andrew V. Stachulski,Steven Rossington,Deborah Stanford,Stephen Rigby,Nigel Scrutton,Pierre Lafite,Colin Levy,David Leys, Journal of Biological Chemistry DOI: 10.1074/jbc.M109.056630
October 2009 Structural Basis for the Mechanism of Respiratory Complex I Journal Paper, J. M. Berrisford,L. A. Sazanov, Journal of Biological Chemistry 284 DOI: 10.1074/jbc.M109.032144
September 2009 Structure-Guided Directed Evolution of Alkenyl and Arylmalonate Decarboxylases. Journal Paper, Krzysztof Okrasa,Matthew Wilding,Mark Goodall,Nina Baudendistel,Bernhard Hauer,Jason Micklefield,Colin Levy,David Leys, Angewandte Chemie 48 (41) DOI: 10.1002/anie.200904112
September 2009 Molecular Architecture of the Mos1 Paired-End Complex: The Structural Basis of DNA Transposition in a Eukaryote Journal Paper, Julia Richardson,Sean D. Colloms,David J. Finnegan,Malcolm Walkinshaw, Cell 138 DOI: 10.1016/j.cell.2009.07.012 PMID: 19766564
September 2009 Activation of Rho GTPases by DOCK Exchange Factors Is Mediated by a Nucleotide Sensor Journal Paper, Jingjie Yang,Ziguo Zhang,Mark Roe, Marshall,David Barford, Science 325 DOI: 10.1126/science.1174468
September 2009 Structure and RNA binding of the mouse Pumilio-2 Puf domain. Journal Paper, Huw Jenkins, Baker-Wilding,Thomas Edwards, Journal of Structural Biology 167 (3) DOI: 10.1016/j.jsb.2009.06.007
August 2009 Structural insights into regioselectivity in the enzymatic chlorination of tryptophan. Journal Paper, Zhu, de Laurentis, Leang, Herrmann, Ihlefeld, van Pee,James Naismith, Journal of Molecular Biology 391 (1) DOI: 10.1016/j.jmb.2009.06.008
August 2009 Cloning and characterisation of dihydrodipicolinate synthase from the pathogen Neisseria meningitidis Journal Paper, Sean Devenish, Huisman, Parker,Andrea Hadfield, Gerrard, Biochimica et Biophysica Acta (BBA) 1794 (8) DOI: 10.1016/j.bbapap.2009.02.003
July 2009 Crystal Structures of Wzb of Escherichia coli and CpsB of Streptococcus pneumoniae, Representatives of Two Families of Tyrosine Phosphatases that Regulate Capsule Assembly Journal Paper, Gregor Hagelueken, Huang, Mainprize, Whitfield,James Naismith, Journal of Molecular Biology PMID: 19616007
July 2009 Structural Basis for Functional Tetramerization of Lentiviral Integrase Journal Paper, Stephen Hare, Di Nunzio,Alfred Labeja,Jimin Wang,Alan Engelmann,Peter Cherepanov, PLOS Pathogens 5(7) DOI: 10.1371/journal.ppat.1000515
June 2009 Crystal structure and biophysical properties of Bacillus subtilis BdbD: An oxidizing thiol:disulfide oxidoreductase containing a novel metal site Journal Paper, Allison Lewin,Oliver Hecht,Mirja Carlsson Möller,Geoffrey R Moore,Lars Hederstedt,Nick le Brun,Allister Crow, Journal of Biological Chemistry
June 2009 Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP Journal Paper, Bishop,Karl Harlos, O'Callaghan, Jones,Christian Siebold,Alexandru Aricescu, Nature Structural & Molecular Biology 16 (7) DOI: 10.1038/nsmb.1607
May 2009 Structural insight into the quinolone–DNA cleavage complex of type IIA topoisomerases Journal Paper, Ivan Laponogov,Maninder K Sohi,Dennis A Veselkov,Xiao-Su Pan,Ritica Sawhney,Andrew W Thompson,Katherine McAuley,L Mark Fisher,Mark R Sanderson, Nature Structural & Molecular Biology 16 DOI: 10.1038/nsmb.1604
May 2009 Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A Journal Paper, Grazyna Kochan,Ewa Pilka,Frank von Delft,Udo Oppermann,Wyatt Yue, Journal of Molecular Biology
May 2009 Crystallization and preliminary X-ray analysis of a bifunctional catalase-phenol oxidase from Scytalidium thermophilum Journal Paper, Arwen Pearson,Simon Phillips,Michael McPherson,Didem Kocabas,U Bakir,Z Bakir,Chi Hung Trinh, Acta Crystallographica Section F Structural Biology and Crystallization Communications 65 DOI: 10.1107/S1744309109012007
May 2009 Structure of the Michaelis complex of beta-mannosidase, Man2A, provides insight into the conformational itinerary of mannoside hydrolysis Journal Paper, Wendy Offen, Zechel, Withers, Gilbert, Davies, Chemical Communications 18 DOI: 10.1039/b902240f
May 2009 Structure of a trypanosomatid mitochondrial cytochrome c with heme attached via only one thioether bond and implications for the substrate recognition requirements of heme lyase Journal Paper, Vilmos Fulop, Sam, Ferguson, Ginger, Allen, Federation of European Biochemical Societies Journal 276 (10) DOI: 10.1111/j.1742-4658.2009.07005.x
May 2009 Crystal structure of Escherichia coli polynucleotide phosphorylase core bound to RNase E, RNA and manganese: implications for catalytic mechanism and RNA degradosome assembly Journal Paper, Salima Nurmohamed, Vaidialingam, Callaghan,Ben Luisi, Journal of Molecular Biology 389 (1) PMID: 19327365
April 2009 Structural insights into formation of an active signaling complex between Rac and phospholipase C gamma 2 Journal Paper, Bunney,Olaniyi Opaleye, Vatter, Baxendale, Walliser, Everett, Josephs, Christow, Rodriquez-Lima,Mark Roe, Molecular Cell 34 (2) DOI: 10.1016/j.molcel.2009.02.023
March 2009 Structural and functional studies of the biotin protein ligase from Aquifex aeolicus reveal a critical role for a conserved residue in target specificity Journal Paper, C Tron,Iain McNae,M Nutley,D Clarke,A Cooper,Malcolm Walkinshaw,R Baxter,Dominic Campopiano, Journal of Molecular Biology 387(1) DOI: 10.1016/j.jmb.2008.12.086 PMID: 19385043
March 2009 Structures of Leishmania major orthologues of macrophage migration inhibitory factor Journal Paper, Julia Richardson,Lesley S. Morrison,Nicholas D. Bland,Sandra Bruce,Graham H. Coombs,Jeremy C. Mottram,Malcolm D. Walkinshaw, Biochemical and Biophysical Research Communications 380 DOI: 10.1016/j.bbrc.2009.01.030 PMID: 19187777
March 2009 Identification and structural analysis of type I collagen sites in complex with fibronectin fragments. Journal Paper, Michele Christine Erat, Slatter, Millard, Farndale, Campbell,Ed Lowe,John Vakonakis, Proceedings of the National Academy of Sciences 106 (11) DOI: 10.1073/pnas.0812516106
February 2009 Crystal Structure of a Catalytically Active, Non-Toxic Endopeptidase Derivative of Clostridium Botulinum Toxin A Journal Paper, Geoffrey Masuyer,Nethaji Thiyagarajan,Peter James,Philip Marks,John Chaddock,Ravi Acharya, Biochemical and Biophysical Research Communications 381 (1) DOI: 10.1016/j.bbrc.2009.02.003
January 2009 The Crystal Structure of an Avian IgY-Fc Fragment Reveals Conservation with both Mammalian IgG and IgE Journal Paper, Alexander I. Taylor,Stella M. Fabiane,Brian J. Sutton,Rosaleen A. Calvert, Biochemistry 48 DOI: 10.1021/bi8019993 PMID: 19115948
January 2009 Crystallization and preliminary structural studies of champedak galactose-binding lectin Journal Paper, Gabrielsen, Riboldi-Tunnicliffe, Abdul-Rahman, Mohamed, Ibrahim, Hashim, Isaacs, Cogdell, Acta Crystallographica Section F Structural Biology and Crystallization Communications 65 DOI: 10.1107/S1744309109029303
November 2008 Crystal structure and carbohydrate analysis of Nipah virus attachment glycoprotein: a template for antiviral and vaccine design Journal Paper, Thomas Bowden,Max Crispin, Harvey,Alexandru Aricescu,Jonathan Grimes, Jones,Dave Stuart, Journal of Virology 82 DOI: 10.1128/JVI.01344-08
October 2008 The postfusion structure of baculovirus gp64 supports a unified view of viral fusion machines. Journal Paper, Kadlec, Loureiro, Jones,Nicola Abrescia,Dave Stuart, Nature Structural & Molecular Biology 10 PMID: 18776902
October 2008 Molecular Architecture of the "Stressosome" a Signal Integration and Transduction Hub Journal Paper, Jon Marles-Wright,Tim Grant,Olivier Delumeau,Gijs van Duinen,Susan Firbank,Peter J Lewis,James W Murray,Joseph A Newman,Maureen Quin,Paul Race, Science 322 DOI: 10.1126/science.1159572
October 2008 Crystal structure of a stable dimer reveals the molecular basis of serpin polymerization. Journal Paper, Massayuki Yamasaki,Li Wei Li,Daniel Johnson,Jim Huntington, Nature 455(7217) PMID: 18923394
September 2008 Crystallization and preliminary X-ray analysis of the O-carbamoyltransferase NovN from the novobiocin-biosynthetic cluster of Streptomyces spheroides Journal Paper, Inmaculada Gómez García,Caren Freel Meyers,Christopher Walsh,David Lawson, Acta Crystallographica Section F Structural Biology and Crystallization Communications 64 DOI: 10.1107/S1744309108030145
August 2008 Macromolecular crystallography at Diamond Light Souce: Automation and pathogenic sample environment Journal Paper, Dave Hall,Alun Ashton,Jose Brandao-Neto,David Butler,Liz Duke,Gwyndaf Evans,Ralf Flaig, Foster,Paul Gibbons,Mic Harding,Mike Latchem,Karl Levik,Katherine McAuley,James O'Hea,Geoff Preece,James Sandy, Waterman, Williams,Richard Woolliscroft,Thomas Sorensen, Acta Crystallographica Section A Foundations of Crystallography 64
August 2008 Experience from operation and commissioning of the Phase 1 MX beamlines at Diamond Light Source Conference Paper, Ralf Flaig,Alun Ashton,Jose Brandao-Neto,Liz Duke,Gwyndaf Evans, Foster,Paul Gibbons,Arno Grant,Dave Hall,Mike Latchem,Karl Levik,Katherine McAuley,James O'Hea,Geoff Preece,James Sandy,Thomas Sorensen,David Waterman,Richard Woolliscroft, null
June 2008 The FACT Spt16 'peptidase' domain is a histone H3'H4 binding module Journal Paper, Tobias Stuwe,Michael Hothorn,Erwan Lejeune,Vladimir Rybin,Miriam Bortfeld,Klaus Scheffzek,Andreas Ladurner, Proceedings of the National Academy of Sciences 105 no 26 DOI: 10.1073/pnas.0712293105
March 2008 Crystallization and preliminary X-ray analysis of RsbS from Moorella thermoacetica at 2.5 A resolution Journal Paper, Susan Firbank,Rick Lewis,Jon Marles-Wright,Joseph A Newman,Maureen Quin, Acta Crystallographica Section F Structural Biology and Crystallization Communications 64 (Pt 3) PMID: 18323607
January 2008 Structure of the topoisomerase IV from S. pneumoniae with a DNA target and quinolone drug Poster, Ivan Laponogov,Maninder Sohi,Dennis Veselkov, Pan, Sawhney, Thompson,Mark Fisher,Mark Sanderson, Acta Crystallographica Section A Foundations of Crystallography 64
August 2007 Commissioning Progress at Diamond Light Source. Conference Paper, Ralf Flaig, null