I studied Physics Engineering at Politecnico di Milano (Milano, Italy), where I earned a bachelor’s degree followed by a master’s degree. Both of them consisted mainly of solid state physics classes, with a particular focus on semiconductors (for electronics and photonics application) and magnetic nanostructures. My first experience in research was at the European Synchrotron Radiation Facility (Grenoble, France), where I spent 10 months working as a trainee for my master thesis project.
Read more about Davide Pincini
What is your research background?
For my undergraduate degree I studied Biomedical Sciences at the University of Reading. During my second year I did a structural biology based 6 week UROP placement, spending the majority of my time working in MPL and the Research Complex at Harwell. The placement concluded with an intensive data collection weekend on the B23 beamline. I then continued this research back in the university lab for my final year research project. Before starting my PhD I spent a year away from science working as an au pair in Norway.
What is your PhD project with Diamond?
My PhD project, joint with the University of Reading and Diamond Light Source, is focused on an outer membrane protein in Chlamydia and extends from the research conducted during my undergraduate degree. My main motivation lies in obtaining a high-resolution crystal structure, which so far has involved optimisation of protein expression and purification using the facilities at the Research Complex. Part of my time has been spent doing molecular dynamics simulations through collaborative work with Oxford University, as well as developing functional assays in the microbiology labs in Reading. Super resolution microscopy work at the Central Laser Facility is also underway for visualisation of protein mutant clustering within the E. coli outer membrane.
What are your plans for after your studentship?
Once I’ve completed my studentship in a year’s time I’d like to continue with lab based research in the field of structural biology, either as a post doc or in industry.
Would you recommend a Diamond studentship to others?
I would undoubtedly recommend a PhD studentship at Diamond to others. Not only are there fantastic facilities on hand but there is such a wide range of expertise available within every lab and around the ring. Diamond holds frequent seminars in which to discover more about other projects on site, as well as training events, and opportunities to showcase your own research.
Diamond Light Source is the UK's national synchrotron science facility, located at the Harwell Science and Innovation Campus in Oxfordshire.
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