I studied Physics Engineering at Politecnico di Milano (Milano, Italy), where I earned a bachelor’s degree followed by a master’s degree. Both of them consisted mainly of solid state physics classes, with a particular focus on semiconductors (for electronics and photonics application) and magnetic nanostructures. My first experience in research was at the European Synchrotron Radiation Facility (Grenoble, France), where I spent 10 months working as a trainee for my master thesis project.
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Foot-and-mouth disease virus (FMDV) is a single-stranded positive-sense RNA virus in the picornavirus family. Picornaviruses have small genomes and rely on host cell factors to replicate. FMDV subverts cellular lipid trafficking pathways to generate distinctive membrane structures, called replication organelles that serve as platforms for viral replication. FMDV encodes a number of proteins essential for its replication, such as the RNA polymerase 3Dpol, which are likely to interact with each other and with a number of unidentified cellular proteins to form a replication complex where new copies of the viral genome can be generated. The cellular components required for formation of either the membraneous replication organelles or the replication complex remains unknown.
Recent research by the Tuthill group and their collaborators have identified a number of candidate host-cell proteins that are required for viral replication. This new information, along with super-resolution fluorescence microscopy and electron microscopy facilities at Pirbright and Diamond combines to produce a timely opportunity to understand FMDV replication in more detail than ever possible before . This project will combine virology and microscopy at Pirbright with cutting edge multi-modal imaging approaches at Diamond in order to identify and characterize the cellular factors required for viral replication.
This studentship is linked with the BBSRC Oxford Interdisciplinary Bioscience Doctoral Training Partnership.
Applications to this studentship will open in early 2018.
Diamond Light Source Ltd. holds an Athena SWAN Bronze Award, demonstrating their commitment to provide equal opportunities and to advance the representation of women in STEM/M subjects: science, technology, engineering, mathematics and medicine.
Diamond Light Source is the UK's national synchrotron science facility, located at the Harwell Science and Innovation Campus in Oxfordshire.
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