Diamond Light Source is the UK’s national synchrotron science facility. Located on the Harwell Science & Innovation Campus in Oxfordshire a 20 minute drive south of Oxford in a designated Area of Outstanding Natural Beauty, Diamond Light Source conducts world-class research in virtually all fields of science and offers rewarding career opportunities covering both technical and scientific disciplines.

We are seeking an innovative and enthusiastic individual with significant experience in software and algorithm development in X-ray crystallography, preferably in the field of membrane proteins. The candidate will be tasked with the development of methods to analyse and combine multiple crystal diffraction data from membrane proteins in the presence of significant and varying anisotropy.
The candidate will work within the methods development group of Dr Gwyndaf Evans and work in close collaboration with the Diamond Membrane Protein Laboratory staff and users. Experience with existing techniques for the analysis of multicrystal data sets is essential and a strong working knowledge of C/C++ and Python is a must. A good working knowledge of protein crystallographic packages such as CCP4 and Phenix is also helpful.

PDRA in membrane protein crystal data analysis - To develop algorithms and software for the combination of multicrystal membrane protein data sets in the presence of significant anisotropy.

• Development of novel data analysis methodology for membrane protein crystallography;
• Develop and maintain expertise in a scientific field;
• Work closely with other scientific and technical staff to produce designs for new systems, equipment or processes;
• Collaborate with Diamond and MPL users and staff research within area of expertise;
• Contribute to scientific papers from external or in-house research;
• Local contact support to MPL users by setting up and providing advice and guidance on the best approach to data analysis.

• PhD or equivalent in structural biology or related disciplines;
• Track record in the development of multicrystal data analysis methodology;
• Experience in the analysis of membrane protein crystal diffraction data;
• Experience in diffraction data collection and analysis;
• Strong working knowledge of C/C++ and Python programming languages;
• Experience in providing expert support to end-users;
• Good interpersonal, communication, organizational and presentational skills;
• Ability to interact with staff and facility users at all levels;
• Ability and initiative to get to the heart of the problem and take it effectively through to completion;
• Ability to work as part of a multi-disciplinary team;
• Ability to work flexibly with occasional weekend and out-of hours work;
• Self motivation.

Experience in structural biology.