Laboratory of Biophysics and Surface Analysis, School of Pharmacy, University of Nottingham.
The use of polymeric coatings to guide cell adhesion and proliferation for applications in Tissue Engineering will be presented. Specifically, plasma polymerised allyamine will be introduced, a coating which has recently been successfully used to increase adhesion of a number of cell types to scaffolds in Nottingham including Human Colon Carcinoma cells, Primary Intestinal Myofibroblasts, 3T3 Mouse Fibroblasts and Primary Rat Hepatocytes. Characteristics of this vapour phase coating technique will be illustrated using the example of porous poly(lactic acid) scaffolds where a core-sheath distribution of chemistry has been employed to provide a uniform cell distribution through a 4 mm thick 10 mm diameter disc. The interrelationship of cell distribution and nanostructured surface chemistry on planar surfaces will be presented supported by XPS and AFM data. The potential of X-PEEM in this system will be highlighted.
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