Tina Geraki

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Tina Geraki is Senior Support Scientist on I18, the Microfocus Spectroscopy beamline. She joined Diamond in 2008 after positions at City University London, SRS Daresbury Laboratory and a short spell in industry.

Email: tina.geraki@diamond.ac.uk
Tel: +44 (0) 1235 778898

Key Research Area

Key Research Area

  • X-ray microprobe techniques in biomedical applications 
  • X-ray absorption spectroscopy
  1. Research Expertise
  2. Collaborations
  3. Publications
  4. Biography
Research Expertise -

Current Research Interests

The role of metals is one of the many aspects investigated in a wide range of diseases and treatments. Synchrotron microprobes are powerful instruments in metal related research as they allow the spatial localisation of elements even at trace amounts therefore facilitating the investigation of changes in their levels or location as a product of disease or treatment. Further insights can be gained with x-ray absorption spectroscopy that can provide chemical information about the metal in question and its immediate environment. For examples of such work undertaken on I18 see "Collaborations".

Collaborations - +

Collaborations

Metals and breast cancer: With M. Farquharson, McMasters University, Canada, we are investigating the association of the levels of endogenous elements like Ca, Fe, Cu and Zn with a wide range of biomarkers in different breast cancer categories (eg invasive and in-situ, oestrogen receptor positive and negative). We are ultimately looking for associations that affect response to treatment, severity of disease and overall prognosis.     

Metals and retinal function: With M. Ugarte, Moorfields Eye Hospital, we are looking into the role of metals in processes relating to retinal disease and aging. Recent experiments indicate a disruption of copper levels in one of the neurologically active layers of the retina associated with diabetic retinopathy.
 
Metal-based drugs for cancer therapy:  With M. Hannon, PSIBS, Birmingham University, we are studying the action of certain metallocylinder drugs developed for cancer therapy. Synchrotron microprobe mapping is used to confirm drug delivery in the cell and XANES analysis is a way of investigating changes to the chemical environment of the metal atom.
Publications - +

Selected Recent Publications

  • Al-Ebraheem, A., Geraki, K., Leek, R., Harris, A. L., and Farquharson, M. 2013. The Use of Bio-Metal Concentrations Correlated with Clinical Prognostic Factors to Assess Human Breast Tissues. X-Ray spectrometry 42 330-336
  • A.L. Neal, K. Geraki, S. Borg, P. Quinn, J.F. Mosselmans, H. Brinch-Pedersen, P.R. Shewry 2013. Iron and Zinc complexation in wild-type and ferritin-expressing wheat grain: implications for mineral transport into developing grain. JBIC 18(5) 557:570
     
  • M. Ugarte, G.W. Grime, G. Lord, K. Geraki, J.F. Collingwood, M. E. Finnegan, H. Farnfield, M. Merchant, M. Bailey, N.I. Ward, P. Foster, P.N. Bishop and N.N. Osborne. 2012. Concentration of various trace elements in the rat retina and their distribution in different structures.  Metallomics 12(4) 1245:1254
     
  • M.J. Farquharson A. Al-Ebraheem K. Geraki. R. Leek and A. Harris. 2009. Zinc presence in invasive ductal carcinoma of the breast and its correlation with oestrogen receptor status. Physics in Medicine and Biology 54 4213-4223
Biography - +

Biography

Tina Geraki is Senior Support Scientist on I18, the Microfocus Spectroscopy beamline. She joined Diamond in 2008 after positions at City University London, SRS Daresbury Laboratory and a short spell in industry. Her principal scientific interest is in the application of x-ray microprobe and absorption spectroscopy techniques in biomedical problems.