Circular Dichroism (CD) is the spectroscopic technique to study in solution a wide variety of chiral materials such as small molecules (drugs), polymers and biopolymers (nucleic acids, proteins, carbohydrates and lipids). In particular for proteins, knowledge of the structure-function relationship is essential to dissect the mode of action and to identify new targets for novel drug therapeutics.
For rigid and well structured systems, like enzymes and globular proteins, CD is a low-resolution technique compared to NMR and X-ray crystallography. However, a third to half of mammalian proteins have natively disordered structures that are unsuitable for NMR and X-ray crystallography. CD is the ideal technique to investigate protein/ligand binding interactions of these important systems involved in signal transduction of normal and tumour cells.
B23 produces a collimated beam of small cross section at the sample (about 1mm (V) x 2mm (H)) enabling the measurement of smaller volumes of sample solutions several times better than commercial CD instruments. High photon flux across the UV region improves the signal-to-noise of CD measurements.
B23 is used by researchers in the biological, biochemical, chemical, pharmaceutical, and crystallographic sciences to examine proteins, nucleic acids, carbohydrates, biopolymers, small ligands and the interactions of these molecules to form macromolecular and drug complexes.
B23 Roadshow Series on Material Science - Emerging Prospects for Chiroptical Materials and Interfaces
Date: Tuesday 18 March 2014
Venue: Diamond Light Source, Oxfordshire
Diamond Light Source – University of Liverpool
On the 18th March 2014, Diamond Light Source (DLS), together with the University of Liverpool will hold a one-day workshop dedicated to material science research, with a particular view to promote the synchrotron based CD beamline B23 for these emerging chiroptical materials and interfaces. The event will be held at Diamond Light Source, Oxfordshire.
The workshop is free to attend and includes refreshments and lunch, but registration is limited to 40 places. Successful registrants will be expected to reconfirm their place nearer the time in order to give those on a reserved list a chance to take up any cancellation places.
Xingbing Zeng, Sheffield University
Konstantin Borishenko – Oxford University
Luigi Calzolai – European Joint Research Centre Institute for Health and Consumer Protection, Italy
Adam Perriman – Bristol University
Giuliano Siligardi & Rohanah Hussain, Diamond Light Source B23
This will be the third event in a series of Road shows to highlight Diamond Light Source B23 throughout the country. The next event will be the User Meeting in September 2014. If you are interested in participating in future events please email Rohanah Hussain.
Diamond Light Source is the UK's national synchotron science facility, located at the Harwell Science and Innovation Campus in Oxfordshire.
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