Anna Warren

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Anna Warren is a Senior Support Scientist on VMXm.  She joined Diamond in 2010 on I19, before moving to I24 as a Postdoctoral Research Associate in 2012.  She joined VMXm in May 2015.

Email: anna.warren@diamond.ac.uk
Tel: +44 (0) 1235 567455

Key Research Area

Key Research Area

  • Methods development
  • Beamline instrumentation
  • X-ray microtomography

Latest publiations

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  1. Research Expertise
  2. Publications
Research Expertise -

Current Research Interests

Macromolecular crystallography is moving towards even more challenging target proteins which often crystallise on much smaller scales and are frequently mounted in opaque or highly refractive materials. It is therefore essential that X-ray beamline technology develops in parallel to accommodate such difficult samples.  I am involved in developing projects into the investigation of <10 micron crystals for the study on VMXm.  These advancements include novel mouting procedures for such small crystals, as well developments into the visualisation of very small crystals.

I have also been developing beamline techniques to aid with the visualisation of very small crystals or samples which are impossible to locate due to the way they are mounted.  Such materials include membrane proteins mounted in lipidic cubic phase.  The main technique I am involved in developing is X-ray micro-tomography on the MX beamlines.  This can be used to help locate difficult samples, and also used as a technique for determining the shape and faces of crystals.

 

Publications - +

Publications

    • J. H. Tutt, D. J. Hall, M. R. Soman, A. D. Holland, A. J. Warren, T. Connolley and A. M. Evagora. Development of EM-CCD-based X-ray detector for synchrotron applications. Electron. Lett., 2014, 50(17), 1224-1226
    • J. H. Tutt, D. J. Hall, M. R. Soman, A. D. Holland, A. J. Warren, T. Connolley and A. M. Evagora (2014) Comparison of EM-CCD and scientific CMOS based camera systems for high resolution X-ray imaging and tomography applications. J. Instrum., 9, P06017.
    • M. R. Warren, T. L. Easun, S. K. Brayshaw, R. J. Deeth, M. W. George, A. L. Johnson, S. Schiffers, S. J. Teat, A. J. Warren, J. E. Warren, C. C. Wilson,  C. H. Woodall, and P. R. Raithby (2014) Solid-State Interconversions: Unique 100% Reversible Transformations between the Ground and Metastable States in Single-Crystals of a series of Nickel(II) Nitro Complexes. Chem. Eur. J., 20, 5468-5477.
    • M. A. Makhyouna, R. A. Palmer, A. A. Soayeda, H. M. Refaata, D. E. Basher, J. Raftery, C. M. C. Lobley, A. J. Warren, T. Sorensen and M. Ladde (2014) The Ni(II) Complex of 2-Hydroxy-Pyridine-N-Oxide 2-Isothionate: Synthesis, Characterization, Biological Studies, and X-ray Crystal Structures using (1) Cu Kα Data and (2) Synchrotron Data. J. Mater. Sci. Nanotechnol., 1: 301.
    • G. Paterno, A. J. Warren, J. Spencer, G. Evans, V. Garcia Sakai, J. Blumberger and F. Cacialli (2013) Micro-focused X-ray diffraction characterization of high quality [6,6]-phenyl C61 butyric acid methyl ester single crystals without solvent impurities. J. Mater. Chem. C, 1, 5619-5623.
    • A. J. Warren,  W. Armour, D. Axford, M. Basham, T. Connolley, D. R. Hall, S. Horrell, K. E. McAuley, V. Mykhaylyk, A. Wagner and G. Evans (2013) Visualization of membrane protein crystals in lipid cubic phase using X-ray imaging. Acta Cryst., D69, 1252-1259.
    • A. A. Ayi, A. D. Burrows, M. F Mahon and A. J. Warren (2013) Trans-[PtCl2(NH2C6H4CO2H)2]: a platinum complex forming a two-dimensional hydrogen-bonded network.Int. J. Phys. Sci., 8 (30), 1546-1550.
    • M. R. Warren, S. K. Brayshaw, L. E. Hatcher, A. L. Johnson, S. Schiffers, A. J. Warren, S. J. Teat, J. E. Warren and C. H. Woodall (2012) Photoactivated linkage isomerism in single crystals of nickel, palladium and platinum di-nitro complexes - a photocrystallographic investigation. Dalton Trans. 41, 13173-13179.
    • A. D. Burrows, M. F. Mahon, C. L. Renouf, C. Richardson, A. J. Warren and J. E. Warren (2012) Dipyridyl ß-diketonate complexes and their use as metalloligands in the formation of mixed-metal coordination networks. Dalton Trans. 41, 4153-4163.
    • A. D. Burrows, M. F. Mahon, P. R. Raithby, A. J. Warren, S. J. Teat and J. E. Warren (2012) The effect of carboxylate N,N'-ditopic ligand lengths on the structures of copper and zinc coordination polymers. CrystEngComm. 14, 3658-3666.
    • L. E. Hatcher, M. R. Warren, D. R. Allan, S. K. Brayshaw, A. L. Johnson, S. Fuertes, S. Schiffers, A. J. Stevenson, S. J. Teat, C. H. Woodall and P. R. Raithby (2011) Metastable linkage isomerism in [Ni(Et4dien)(NO2)2]: A combined thermal and photocrystallographic structural investigation of a nitro/nitrito interconversion. Angew. Chem. Int. Ed. 50, 36, 8371-8274.
    • A. D. Burrows, D. J. Kelly, M. F. Mahon, P. R. Raithby, C. Richardson and A. J. Stevenson (2011) Silver coordination networks and cages based on a semi-rigid bis (isoxazoyl) ligand. Dalton Trans. 40, 5483-5493.
    • S. K. Brayshaw, S. Schiffers, A. J. Stevenson, S. J. Teat, M. R. Warren, R. D. Bennett, I. V. Sazanovich, A. R. Buckley, J. A. Weinstein and P. R. Raithby (2011) Highly efficient visible-light driven photochromism: Developments towards a solid-state molecular switch operating through a triplet-sensitised pathway. Chem- Eur. J. 17, 16, 4385-4395.
    • A. D. Burrows, C. G. Frost, M. F. Mahon, P. R. Raithby, C. L. Renouf, C. Richardson and A. J. Stevenson (2010) Dipyridyl ß-diketonate complexes: Versatile polydentate metalloligands for metal-organic frameworks and hydrogen-bonded networks. Chem. Commun. 46, 5067-5069.
    • A. D. Burrows, C. G. Frost, M. F. Mahon, P. R. Raithby, C. Richardson and A. J. Stevenson (2010) Solid state interconversion of cages and coordination networks via conformational change of a semi-rigid ligand. Chem. Commun. 46, 5064-5066.