Simone Culurgioni

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Simone Culurgioni is a Post-Doctoral Research Associate working in the Group of Dr Martin Walsh. He completed his PhD in Biochemistry at the Universidad Autonoma of Madrid in 2010. Before joining Diamond he worked at the IEO in Milan. His main research interest at Diamond is the study of structure of the bacterial NO sensor proteins to elucidate their molecular mechanism in transcription regulation. This work is being carried out in collaboration with Groups at the University of Strathcylde and the Central Laser Facility at RCaH.

Email: simone.culurgioni@diamond.ac.uk
Tel: 01235778435

Key Research Area

Culurgioni S, Mapelli M. (2013). Going vertical: functional role and working principles of the protein Inscuteable in asymmetric cell divisions. Cell Mol Life Sci. 2013 Mar 21.

Culurgioni S, Muñoz IG, Moreno A, Palacios A, Villate M, Palmero I, Blanco FJ, Montoya G. (2012) The crystal structure of the ING4 dimerization domain reveals the functional organization of the ING family of chromatin binding proteins. J. Biol. Chem. 287(14):10876-84.

Culurgioni S, Alfieri A, Pendolino V, Laddomada F, Mapelli M. (2011). Insc and NuMA compete for LGN binding to orient the mitotic spindle orientation during Asymmetric Cell Divisions. Proc Natl Acad Sci USA. 108(52):20998-1003.

Culurgioni S, Muñoz IG, Palacios A, Redondo P, Blanco FJ, Montoya G (2010). Crystallization and preliminary X-     ray diffraction analysis of the dimerization domain of the tumour suppressor ING4. Acta Crystallogr Sect F            66,    567-570.

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  1. Collaborations
  2. Publications
Collaborations -

Collaborations

 

Dr Nick Tucker - Lecturer in Medical Microbiology, University of Strathclyde, Glasgow

Dr Marina Mapeli - Head of Molecular basis of asymmetric cell division group, European Institute of Oncology, Milan

Dr Phil Biggin - Head of Computational Approaches to Receptor Dynamics and Ligand-Binding group, University of Oxford, Oxford

Dr Ten Feizi - Director of the Glycosciences Laboratory, Imperial College, London.

 

Publications - +

Publications

 

Culurgioni S, Mapelli M. Going vertical: functional role and working principles of the protein Inscuteable in asymmetric cell divisions. Cell Mol Life Sci.70(21),4039-4046 (2013).
 
Culurgioni S, Muñoz IG, Moreno A, Palacios A, Villate M, Palmero I, Blanco FJ, Montoya G. Crystal structure of inhibitor of growth 4 (ING4) dimerization domain reveals functional organization of ING family of chromatin-binding proteins. J Biol Chem. 287(14),10876-84 (2012).
 
Culurgioni S, Alfieri A, Pendolino V, Laddomada F, Mapelli M. Inscuteable and NuMA proteins bind competitively to Leu-Gly-Asn repeat-enriched protein (LGN) during asymmetric cell divisions. Proc Natl Acad Sci USA108(52), 20998-1003 (2011).

 

Culurgioni S, Muñoz IG, Palacios A, Redondo P, Blanco FJ, Montoya G. Crystallization and preliminary X-ray diffraction analysis of the dimerization domain of the tumour suppressor ING4. Acta Crystallogr Sect F. 66(5), 567-570 (2010).