Membrane protein crystals are often very small, extremely fragile, poorly ordered (highmosaicity) and very sensitive to radiation damage. Collecting data from such crystals is not a straightforward task and the resolution of the X-ray diffraction data not only depends on the crystal quality but also on the characteristics of the data collection apparatus.
The proximity of the X-ray source to MPL provides a unique advantage in alleviating problems in crystal transport and facilitates a quick turn around between design of an experiment and its execution. MPL combines recently developed high throughput technologies for protein production and crystallisation with the latest developments in X-ray diffraction data collection systems at Diamond. This allows MPL users to characterise early stage crystal hits and determine their promise for optimisation trials leading to a rapid project progression.
Facilities available at the MPL
Diamond Light Source is the UK's national synchrotron science facility, located at the Harwell Science and Innovation Campus in Oxfordshire.
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