This Structure Gallery shows some examples of membrane protein structures successfully solved by MPL researchers and MPL users/collaborators.
The biogenic amine histamine is an important pharmacological mediator involved in pathophysiological processes such as allergies and inflammations. Histamine H1 receptor (H(1)R) antagonists are very effective drugs alleviating the symptoms of allergic reactions.
The structure of bacterial homologue of the Apical Sodium dependent Bile Acid Transporter (ASBT) is a target for hypercholesterolemia drugs since it can affect the level of cholesterol in the blood. It is known that by blocking ASBT, bile acid levels returning to the liver are lowered, the liver therefore converts more cholesterol into bile acids, which lowers the level of cholesterol in the blood.
Hu NJ, Iwata S, Cameron AD, Drew D. “Crystal structure of a bacterial homologue of the bile acid sodium symporter ASBT”. Nature 478:408-11 (2011).
Monoacylglycerol lipases (MGLs) catalyse the hydrolysis of monoacylglycerol into free fatty acid and glycerol. MGLs have been identified throughout all genera of life and have adopted different substrate specificities depending on their physiological role. In humans, MGL plays an integral part in lipid metabolism affecting energy homeostasis, signalling processes and cancer cell progression. In bacteria, MGLs degrade short-chain monoacylglycerols which are otherwise toxic to the organism.
McCusker, E. C., Bagnéris, C., Naylor, C. E., Cole, A. R., D'Avanzo, N., Nichols, C. G., & Wallace, B. A. “Structure of a bacterial voltage-gated sodium channel pore reveals mechanisms of opening and closing”. Nat Communications 3: 1102 (2012).
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