Mick Phillips

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Mick Phillips is a visiting scientist - correlative microscopy research associate.  Mick joined Diamond in August 2013 after working at Asylum Research.

Email: mick.phillips@diamond.ac.uk
Tel: +44 (0) 1235) 778594

Key Research Area

Research

  1. Research
  2. Collaboration
  3. Biography
Research -
Instrumentation and methods for super-resolution microscopy.
 
Transmission x-ray microscopy (TXM) can provide very high resolution, three-dimensional, structural information from a wide range of samples. If we can relate this structural data to complementary chemical or functional information, then TXM becomes a much more powerful tool. Applied to biology, fluorescence microscopy is a well established method for determining the distribution of moieties with specific chemistry (through labeling with fluorescent conjugates), or function (via the expression of fluorescent proteins), but the resolution of even diffraction-limited conventional microscopy is an order of magnitude poorer than that achieved with TXM. We aim to use super-resolution techniques to overcome the diffraction limit and close this resolution gap.
 
A limitation of transmission x-ray microscopy is that samples must be frozen and, as yet, there no commercially available light microscope that allows us to apply super-resolution techniques under cryogenic sample conditions. My job is to produce instrumentation, control and analysis software to meet this need in a way that is accessible to those with specialisms other than instrumentation, and to develop strategies for correlating light microscopy data with that from the x-ray system.
Collaboration - +

Micron, University of Oxford.

Biography - +

Mick obtained his PhD from the University of Nottingham for work on fundamental surface science, combining theoretical work and a number of experimental techniques exploiting synchrotron radiation, followed by a post-doctoral position at Trinity College Dublin, where he worked on novel applications of atomic force microscopy in materials- and life-sciences. He later joined the UK's National Physical Laboratory to work on emerging techniques and standards for the analysis of surfaces and nanoparticles, before joining Asylum Research, a leading instrument manufacturer in this field. Mick joined Nano in 2013. He will bring together developments from a number of institutes across the University of Oxford to provide a super-resolution imaging user facility at Diamond, and establish methods to correlate information from this system with that from synchrotron-based X-ray microscopy.